M. R. MALINOW, J. D. HILL, M. LEES, W. P. MCNULTY AND A. J. OCHSNER III 
115 
change in blood gas and pH values before and 
after infarction. However, these determinations 
were not performed during the later stages of 
shock where differences might have been appar- 
ent. 
Percent Distribution of Cardiac Output. Fif- 
teen minutes after infarction, the percent of 
cardiac output perfusing the midbrain, brain- 
stem, total brain, right atrium, and right ven- 
tricle was significantly increased; the fraction 
directed to the pancreas, spleen, mesentery, and 
thyroid was significantly reduced (Table III). 
The changes in percentage distribution to other 
organs were not statistically significant. 
Forty-five minutes after infarction, there was 
a significant increase in the percentage distri- 
bution of cardiac output to the liver, right 
atrium, left atrium, and right ventricle and de- 
creases to the pancreas, spleen, and mesentery. 
Organs were divided into 2 groups according 
to the changes in the proportion of cardiac out- 
put delivered to them (Table IV). Group A in- 
cluded the brain, heart, liver, and adrenals 
where the percentage distribution of total car- 
Table III. — Blood Flow Distribution (mean ± S. D.; N = 13) 
Percent Cardiac Output Distributed to Each Organ Organ Blood Flow (mI/min/100 g 
Organ 
Control 
Mean 
15 min. 
After 
Infarction 
Mean 
45 min. 
After 
Infarction 
Mean 
Control 
Mean 
15 min. 
After 
Infarction 
Mean 
45 min. 
After 
Infarction 
Mean 
Cerebral hemispheres 
4.94 ± 2.30 
6.31 ± 
2.31 
4.86 ± 
2.17 
69 ± 31 
51 ± 
17* 
35 ± 12t 
Midbrain 
0.16 ± 0.08 
0.24 ± 
0.08t 
0.26 ± 
0.13 
74 ± 56 
58 ± 
20 
59 ± 32 
Brainstem 
0.09 ± 0.06 
0.15 ± 
0.06t 
0.16 ± 
0.11 
30 ± 19 
28 ± 
15 
30 ± 22 
Total Brain 
5.99 ± 2.23 
7.78 ± 
2.38t 
6.41 ± 
2.05 
70 ± 25 
53 ± 
15t 
40 ± lot 
Pancreas 
0.92 ± 0.34 
0.42 ± 
0.23t 
0.48 ± 
0.32t 
112 
± 45 
30 ± 
18t 
29 ± 16t 
GI Tract 
6.96 ± 2.27 
6.23 ± 
2.95 
6.90 ± 
1.80 
43 ± 15 
25 ± 
\zt 
24 ± lit 
Spleen 
0.81 ± 0.67 
0.27 ± 
0.25t 
0.42 ± 
0.34t 
138 
± 83 
SO ± 
26t 
40 ± 28t 
Mesentery 
1.05 ± 0.64 
0.59 ± 
0.52* 
0.66 ± 
0.42* 
16 ± 15 
5 ± 4t 
5 ± 6t 
Liver (hepatic artery) 
13.81 ± 3.67 
16.00 i 
: 6.27 
20.72 ± 6.50t 
90 : 
t 41 
62 ± 
33 
72 ± 33 
Total liver flow (hepatic 
artery and portal vein) 
23.12 ± 4.15 
23.55 ± 7.38 
29.18 ± 6.92t 
55 z 
t 24 
35 ± 
22t 
37 ± 18t 
Right Atrium 
0.20 ± 0.11 
0.32 ± 
0.15t 
0.35 ± 
0.25* 
111 
± 62 
112 :i 
I 70 
115 ± 91 
Left Atrium 
0.24 ± 0.22 
0.33 ± 
0.15 
0.39 ± 
0.27* 
129 
± 90 
115 ± 53 
131 ± 104 
Right Ventricle 
0.77 ± 0.28 
1.18 ± 
0.50* 
1.31 ± 
0.84* 
170 
± 68 
151 d 
= 62 
168 ± 145 
Left Ventricle 
5.06 ± 1.80 
4.50 ± 
0.77 
4.74 ± 
1.50 
300 
± 118 
157 d 
r 53t 
151 ± 62t 
Total Heart 
6.32 ± 2.15 
6.24 ± 
0.88 
6.83 ± 
2.44 
236 
± 82 
139 ± 47t 
139 ± 63t 
Lungs 
0.84 ± 0.51 
0.58 ± 
0.43 
0.78 ± 
0.82 
18 ± 12 
8 ± ' 
r* 
9 dt 10 
Kidneys 
13.47 ± 4.26 
11.10 ± 5.19 
11.09 ± 5.25 
466 
± 171 
231 ± 117t 
209 ± 113t 
Skin 
5.62 ± 2.77 
3.70 ± 
1.20 
4.04 ± 
1.32 
8 ± 
4 
4 ± 2t 
3 ± 2t 
Carcass 
43.46 ± 7.97 
46.23 d 
: 9.48 
40.82 d 
: 8.98 
9 ± 
3 
6 ± 2t 
5 ± It 
* Significantly different from controls p<0.05 
% Significantly different from controls p<0.02 
t Significantly different from controls p<0.01 
t Significantly different from controls p<0.001 
The Student's "t" test for paired values was used. 
Table IV.- 
— Comparison of Two Groups of Organs (mean 
± S.E.) 
Percent Distribution of Cardiac Output 
Control 
15 min. 
After 
Infarction 
% Change 
45 min. 
After 
Infarction 
% Change 
Group A* 
26 ± 5.4 
30 ± 6.3 
+ 15 
34 ± 8.4 + 
+31 
Group B** 
74 ± 5.4 
70 ± 6.3 
Blood Flow (ml/min) 
—5 
66 ± 8.4 A 
—11 
Control 
15 min. 
After 
Infarction 
% Change 
45 min. 
After 
Infarction 
% Change 
Total Cardiac Output 
1106 ± 205 
665 ± 200 + 
—40 
606 ± 50t 
-45 
Group A 
295 ± 90 
205 ± 77 A 
—31 
210 ± 81 AA 
—29 
Group B 
811 ± 145 
460 ± 139 + 
—43 
396 ± 106t 
-51 
* Includes brain, heart, liver, and adrenals. 
** Includes all remaining parts of the body. 
A P (paired "t" test) <0.05 
A P<0.02 
t P<0.01 
t P<0.001 
