H. J. WILKENS, R. STEGER AND N. BACK 
181 
^lActi voted Hageman Factors.-^,, 
•If 
v« 
•i* 
• 
••••• 
Plasminogen 
Prekallikrein 
Plasmin 
i 
Kallikrein 
Kininogen 
Kinin 
Figure 2. — Interrelationship between the fibrinolysin and vasoactive polypeptide syste 
highlighting ability of both plasmin and kallibrein to form kinin directly and indirectly. 
showed varying degrees of cardiac arrhythmias 
and other ECG changes. The saline control dogs 
evidenced more pain at the moment of occlusion 
as indicated by extensive body movement, dis- 
comfort, and vocalization. 
Figs. 4 and 5 summarize the biochemical data. 
All percent changes are based on the control 
base line values after saline or TRASYLOL. 
While standard errors are not indicated, the 
levels of significance (at the .05 level) between 
the control and TRASYLOL-treated groups are 
indicated by a black dot. Hemoconcentration did 
not occur until 24 hours after occulsion, and 
then only in the control dogs. Hematocrit 
(HCT) differences between the control and 
drug-treated groups were significant only at 24 
hours and 8 days. Lee White clotting times 
(LWCT) increased significantly in the control 
dogs during the acute phase and at 5-6 days 
after occlusion. Prothrombin (PROTH) levels 
were decreased throughout the experimen- 
tal period. Fibrinogen (FBGN) levels in- 
creased throughout the experimental period 
in the control dogs. This increase was not as 
prominent in the drug-treated dogs, differing 
significantly from the control dog levels during 
the acute phase. An increase in euglobulin clot 
lysis activities (shortened euglobulin clot lysis 
times — ECLT) was noted for both groups at 30 
minutes post-occlusion, and remained so for the 
TRASYLOL-treated dogs; while the activity 
decreased in the saline control dogs. There were 
kininogen (KNGN) decreases in the TRA- 
SYLOL-treated dogs, which, while not of large 
magnitude initially, did differ significantly from 
the control dogs. Larger decreases did occur 
later in the more chronic phase. No kinin activ- 
ity was detected in either of the two groups 
