R. A. KAINER, C. S. CARD, AND G. P. EPLING 
221 
Figure 2. — Electron micrograph of degeneration of the alveolar epithelium in a part of an alveolus not covered by 
proliferating cells. Arrows indicate basal lamina. Orig. mag. 4300 X. 
Dr. Kainer : This is the one parameter I feel 
secure about. Dr. Alexander is going to talk 
about it. Actually, you can follow the catheter 
through the right heart very nicely. You can 
tell when you're in the right atrium. You can 
tell when you're in the ventricle, and you can 
tell when you go through the valve into the 
pulmonary artery. 
Dr. Johnson: Is this by pressure changes 
that you're measuring? 
Dr. Kainer: By pressure changes on the 
monitor. It's very simple. 
B. C. HOSTZIOLOS, Maryland University, Col- 
lege Park, Md. : Have you any experience with 
urea poisoning or parathion poisoning in cat- 
tle? 
Dr. Kainer : Yes, I did work years ago with 
some urea poisoning. You've brought up a good 
point: where do we go from here? What other 
metabolites do we investigate? We're thinking 
of terpenes. Dr. Don Olsen, who's currently 
conducting work at the Medical School at the 
University of Colorado, is concerned with this. 
H. A. Lyons, Downstate Medical Center, 
Brooklyn, N.Y. : Did you ever think about ana- 
lyzing the blood supply after you gave the 
tryptophan ? 
Dr. Kainer: This has been done by the 
workers at Washington State. 
Dr. Lyons : Because that would be crucial to 
your experiment. 
Dr. Kainer: Yes, They found no essential 
variation. They could not provoke the disease 
in cattle or sheep by intravenous or interperi- 
toneal means. 
Chairman Lenfant: Excuse me, if I may 
elaborate a bit further. Dr. Lyons. I don't think 
that's a real issue. The real issue is to measure 
how much tryptophan goes into the pulmonary 
artery and how much comes out. It seems to me 
