JAMES D. HARDY 
333 
I 
Figure 8. — The lung replanted in puppies grew in both size and functional capacity. 
ployed in lung transplantation in dogs has 
often achieved survival of animals on only the 
replanted lung, when the pulmonary artery 
was ligated immediately or some months after 
the replantation. Again, the success rate is 
greater when the right lung is replanted, due 
to the larger functioning lung tissue mass rep- 
resented by the right lung as compared to the 
left lung. 
Left Lung Replant With Immediate Ligation 
of the Right Pulmonary Artery 
In preparation for study of the immediate bi- 
lateral lung replantation model, we performed 
left lung replantation with immediate ligation of 
the right pulmonary artery through the same 
left thoracotomy incision.** A number of dogs 
survived (Figures 9 and 10). Hill and Shaw 
achieved long-term survival in dogs after pul- 
monary replantation and staged contralateral 
pneumonectomy.*^ 
Bilateral Lung Replantation 
Thus far the discussion has been limited to 
studies performed by us and others using the 
model of a single replanted lung, since for a 
number of years it was believed that the neural 
connections to at least one lung were essential 
to provide adequate reflex respiratory drive to 
permit survival of the animal. This concept 
began to be challenged in the early 1960's, when 
occasionally various groups of workers were 
able to achieve survival of an animal in which 
both lungs had been replanted.*^ *'' It was per- 
haps first well demonstrated by Faber and his 
associates*^ in a series of dogs in 1965 that if 
the right lung were replanted first, the dog could 
survive replantation of the left lung approxi- 
mately one week later in some instances. Still 
