JAMES D. HARDY 
341 
Figure 15.— Dog #BH-35 eight months after bilateral 
lung allografts performed at one operation. 
pulmonary hypertension was produced by the 
repeated injection of a sterile suspension of 
barium into the pulmonary artery over a period 
of from 5 to 6 weeks. Three of the 22 dogs died 
during the period, but 19 dogs eventually de- 
veloped pulmonary hypertension and under- 
went allotransplantation of the left lung. The 11 
dogs that survived removal of the left lung and 
its replacement with an allograft were studied 
from 5 to 12 days postoperatively, but they 
showed no significant reduction in mean right 
ventricular pressure. It was concluded that allo- 
transplantation of the lung did not afford relief 
from pulmonary hypertension during the first 
few days of the postoperative period. Such 
studies must be extended to identify the value 
of lung allotransplantation in long-term surviv- 
ing animals. Weedn, Guenter and Greenfield 
achieved somewhat longer survival of similar 
animals whose chronic pulmonary hypertension 
had been produced by the injection of glass 
beads. 
LUNG TRANSPLANTATION IN MAN 
It would be inappropriate to conclude this dis- 
cussion without noting the accumulated experi- 
ence with lung allotransplantation in man. The 
first human lung transplant was performed in 
1963 following investigation of lung trans- 
plantation in several hundred dogs.'^^ The prob- 
lems met in the human experience were almost 
identical to those which had been encountered 
in the canine model, and transplantation of the 
lung in man was readily accomplished on the 
basis of the previous laboratory experience. 
At the present time lung allotransplantation 
Figure 16. — Chest x-ray in Dog #BH-35 (see Figure 
15) 232 days after bilateral lung allografts. Arterial 
blood gas values are normal. 
