360 
-J 
O 
15.00 
13.00 
11.00 
9.000 
C9 
I 
m 7.000 
o 
5.000 
SURGERY AND TRANSPLANTATION 
OXYGENATOR TEST RESULTS 
— 1 — 
I 
r 1 
1 1 T 
1 I" 
1 1 
1 1 
— r- 
- 
+ 
- 
- 
♦ 
- 
- 
\ ~ 
- 
- 
\+ 
- 
+ 
+ 
- 
- 
_ 
+ 
_ 
- 
___ — ^ 
- 
— T 
+ 
1 
1 
-» 
1 1 1 
1 1 
1 1 
+ 
1 1 
1 1 
1 
-3.000 .0000 3.000 
< — PRE-OP / POST-OP — > CDflYS) 
flTKI.nE.FVIC. INFO. SYS. 71 NOV Zt 
6.000 
9.000 
12.00 
PLOT • t 
Figure 4. — Comparison of hemoglobin values from pre-operative period through post-operative day 10 for "D" 
(membrane) and "T" (bubble) oxygenators. + = standard deviation for bubble oxygenator; — =: standard 
deviation for membrane oxygenator. 
as the perfusion gas for the membrane oxygen- 
ator. 
No significant alterations in hematology or 
biochemistry were noted consequent to perfu- 
sion with the membrane oxygenator. Decreases 
in platelet counts were of less degree than those 
noted with the bubble oxygenator. Hemolysis, 
as indicated by plasma hemoglobin levels, was 
minimal over the four-hour period during per- 
fusion with the membrane oxygenator. 
All animals perfused with the membrane oxy- 
genator utilizing filters survived the perfusion. 
Four of ten animals subjected to perfusion uti- 
lizing the bubble oxygenator expired during the 
period of bypass. 
Autopsy of animals surviving the ten-day ex- 
perimental period indicated no significant path- 
ology directly related to use of the membrane or 
bubble oxygenator. 
From these studies, it is concluded that the 
Dow hollow fiber oxygenator when used with a 
filter is capable of adequately supporting calves 
for periods of at least four hours of total cardio- 
pulmonary bypass. Because it is of low prim- 
ing volume and eliminates a direct blood-oxygen 
interface, it offers certain advantages over the 
disc and bubble type of oxygenators. 
