362 
SURGERY AND TRANSPLANTATION 
OXYGENATOR TEST RESULTS 
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Figure 6. — C!omparison of plasma hemoglobin levels of animals subjected to bypass with "T" (bubble) oxygenator 
and "D" (membrane) oxygenator. 
studying cardiovascular phenomenon still pre- 
dominants in most laboratories. Techniques for 
aorta-coronary artery bypass have been per- 
fected and permit acute and chronic study of 
hemodynamic and functional effects of this pro- 
cedure. It is emphasized that the most impor- 
tant factor in this procedure is practice until 
total coronary occlusion time can be reduced to 
less than 7 minutes. 
In performing surgical manipulation on and 
about the heart, dissection frequently leads un- 
knowingly to transection of the cardiac nerves 
and autonomic imbalance. 
Finally, significant advances have been made 
in establishing colonies of non-human primates 
for experimental studies. Problems of hus- 
bandry, anesthesia, tranquilization, physical con- 
trol while awake, prevention of disease trans- 
mission and post-operative care have been 
solved thus enabling the investigator to make a 
choice of the primate as an experimental animal 
based solely on the scientific merit of the species 
to be used. 
REFERENCES 
1. Pierce, E. C, II, Corrigan, J. J., Kent, B. B,, 
Gate, C. L., Johnson, R. L., and Dreves, A. E. 
Comparative Trauma to Blood in the Disc Oxygen- 
ator and Membrane Lung. Trans. Amer. Soc. Artif. 
Int. Organs 15:33, 1969. 
