398 
SURGERY AND TRANSPLANTATION 
transplantation. Transplantation Proc, II, No. 4: 
546-549, 1970 
8. Brink, A. J., Ed. Organ Transplantation in South 
Africa (Symposium on Organ Transplantation 
6-7, Oct., 1967), University of Stellenbosch Press, 
Stellenbosch, South Africa, 1967. 
9. Murphy, G. P., Brede, H. D., Schoonees, R., 
Groenewald, J. H., Cohen, E., Amiraian, K., and 
Moore, G. E. Biological testing of antilymphocyte 
sera and globulin in the baboon. J. Surg. Oncology, 
3:169-183, 1971. 
10. Balner, H. In vivo evaluation of antihuman 
lymphocyte sera. Federation Proc. 29:117-119, 1970. 
11. Herrmann, J. B., and Murphy, G. P. Renal trans- 
plantation in the rhesus monkey. I. Use of the 
American vascular stapler. Invest. Urol. 2:254-260, 
1964. 
12. Murphy, G. P., Melby, E. C, Mirand, E. A., 
HusER, H. J., Weldon, C. S. Renal transplantation 
in the rhesus monkey. VI. Observations in homo- 
transplanted animals. Invest. Urol. 3:244-267, 1965. 
13. Weber, H. W., Brede, H. D., Retieif, C. P., Retif, 
F. P., and Melby, E. C. The baboon in medical re- 
search: Base-line studies in fourteen hundred 
baboons and pathological observations. In Defining 
the Laboratory Animal: Proceedings of Symposium 
of the National Committee on Laboratory Animals, 
organized by the National Committee on Laboratory 
Animals and the Institute of Laboratory Animal 
Resources, National Research Council, Nat. Acad. 
Sci., Washington, D.C. pp. 528-549, 1971. 
14. Cohen, E. The erythrocyte blood group systems — 
grouping, matching, and role in transplantation. In 
The Baboon in Organ Transplantation. Ed. G. P. 
Murphy, Karger Press, Basel, Switzerland (In 
press), 1972. 
15. Moor-Jankovi^ski, J., Wiener, A. S., and Gordbn, 
E. B. Blood groups of apes and monkeys. I. The 
A-B-0 blood groups in baboons. Transfusion, 4: 
92-100, 1964. 
16. PODLIACHOUK, L., and Dubouch, P. The A-B-0 
groups in a baboon colony in France. Vox Sang. 
18:467-470, 1970. 
17. Wiener, A. S., and Moor-Jankowski, J. Blood 
groups in anthropoid apes and baboons. Science, 
142:67-69, 1963. 
18. Moor-Jankowski, J., Wiener, A. S., Kratochvil, 
C. H., and Fineg, J. Seroprimatology of chimpanzee 
blood group distribution as racial characteristic. 
Science, 152:219-220, 1966. 
19. Moor-Jankom^ski, J., Wiener, A. S., and McRit- 
CHiE, R. Isoantibodies produced in chimpanzees by 
cross-immunization with gibbon red cells. Int. Arch. 
Allergy, 34:386, 1968. 
20. Cohen, E., Gregory, S. G., Dozier, A., Groene- 
wald, J., and Murphy, G. P. Human-type erythro- 
cyte A-B-0 group and leukocyte antigens of Papio 
ursinus, South Africa. Medical Primatology, 1970, 
Proc. 2nd Conf. Exp. Med. and Surg, in Primates. 
New York, 1969, pp. 148-152 (Karger, Basel 1971). 
21. Murphy, G. P., Weber, H. W., Brede, H. D., Retief, 
F. P., Retief, C. P., Van Zyl, J. A., Groenewald, 
J. H., and Van Zyl, J. J. W. The significance of ' 
human ABO blood groups in the survival of un- 
treated baboon renal allotransplants. Amer. Surg. 
35:292-300, 1969. | 
22. IWASAKi, Y. Talmadge, D., and Starzl, T. E. 
Humoral anti-bodies in patients after renal homo- 
transplantation. Transplantation, 5:191-206, 1967. , 
23. DoRF, M. E. and Metzgar, R. S. The distribution of | 
human HLA antigens in chimpanzees and gorillas. 
In Goldsmith and Moor-Jankowski, Medical Prima- 
tologij, 1969, (Karger, Basel, 1971). 
24. Balner, H., Van Leeuwen, A., Dersjant, H., 
Vreeswijk, W., and Van Rood, J. J. Leukocyte 
antigens of chimpanzees and rhesus monkeys. In 
Goldsmith and Moor-Jankowski, Medical Prima- 
tology, 1970, pp. 31-43 (Karger, Basel 1971). 
25. Balner, H., Dersjant, H., Van Leeuwen, A., and 
Van Rood, J. J. Histocompatibility testing in pri- 
mates. Vox Sang. 11:306-314, 1966. 
26. Vagtborg, H., Ed. The baboon, and annotated bib- ! 
liography. The Southwest Foundation for Research j 
and Education, San Antonio, Texas, pp. 1-642, 1964. 
DISCUSSION I 
CHAIRMAN Frank J. Veith: Dr. Murphy's 
excellent presentation is now open for questions 
or discussion. I have a question myself. Ap- , 
parently positive results in testing antilympho- 
cyte globulin (ALG) or antilymphocyte serum 
preparation in monkeys indicates that the serum 
will be effective in man. However, Dr. Nager- 
ian's serum, which has been shown to be effec- 
tive in human volunteers with multiple schero- 
sis, did not have an effect on Dr. Balner's 
monkeys. Therefore, a negative response in 
monkeys would not necessarily mean the serum 
was no good in man. What would be your com- 
ment to that? 
Dr. Murphy: It is always difficult and per- 
haps dangerous to talk about somebody else's 
research. I can only say that we have not found 
this to be so. Dr. Balner has been very generous 
with his time and resources in testing ALG and, 
on occasion, has been requested to give informa- 
tion based on one or two animals or one dose. 
My point today was that you cannot take the 
same dose in man and animals and effectively 
compare it. If there's a negative result, we take 
a little more time and effort, varying the doses 
by numerous degrees (up to ten times) to make 
sure that it really is negative. 
