502 
HEMATOLOGY 
5. Pick, J. R., Goyer, R. A., Graham, J. B., and 
Renwick, J. H. Subluxation of the carpus in dogs, 
an X chromosomal defect closely linked with the 
locus for hemophilia A. Lab. Invest. 17:243, 1967. 
6. Brown, R. C, Swanton, M. C, and Brinkhous, 
K. M. Canine hemophilia and male pseudohermaph- 
roditism: Cytogenetic studies. Lab. Invest. 12:961, 
1963. 
7. Brown, R. C, Castle, W. L. K., Huffines, W. 
D., and Graham, J. B. Pattern of DNA replica- 
tion in chromosomes of the dog. Cytogenetics 
5:206, 1966. 
8. Davis, P. D. Canine double heterozygotes for 
hemophilia A and B. Fed. Proc. 27:627, 1968. 
9. Brinkhous, K. M., Davis, P. D., and McLester, 
W. D. Combined hemophilia A-B in dogs: Af- 
fected males and carrier females from crossbreed- 
ing. XIII International Congress of Hematology, 
Munich. Abstract Volume, p. 221, 1970. 
10. Graham, J. B., Collins, D. L., Godwin, I. D., 
and Brinkhous, K. M. Assay of plasma antihemo- 
philic activity in normal, heterozygous (hemophilia) 
and prothrombinopenic dogs. Proc. Soc. Exp. Biol. 
Med. 77:294, 1951. 
11. Langdell, R. D., Wagner, R. H., and Brinkhous, 
K. M. Effect of antihemophilic factor on one-stage 
clotting tests. J. Lab. Clin. Med. 41:637, 1953. 
12. Brinkhous, K. M., Penick, G. D., Langdell, R. 
D., Wagner, R. H., and Graham, J. B. Physiologic 
basis of transfusion therapy in hemophilia. Arch. 
Path. 61:6, 1956. 
13. Graham, J. B. and Barrow, E. M. The pathogen- 
esis of hemophilia. An experimental analysis of 
the anticephalin hypothesis in hemophilic dogs. J. 
Exp. Med. 106:273, 1957. 
14. Brinkhous, K. M., Langdell, R. D., Penick, G. 
D., Graham, J. B., and Wagner, R. H. Newer ap- 
proaches to the study of hemophilia and hemophil- 
ioid states. J. A. M. A. 154:481, 1954. 
15. Langdell, R. D., Wagner, R. H., and Brinkhous, 
K. M. Antihemophilic factor (AHF) levels follow- 
ing transfusions of blood, plasma and plasma frac- 
tions. Proc. Soc. Exp. Biol. Med. 88:212, 1955. 
16. Graham, J. B., Penick, G. D., and Brinkhous, K. 
M. Utilization of the antihemophilic factor during 
clotting of canine blood and plasma. Amer. J. Phys- 
iol. 164:710, 1951. 
17. Brinkhous, K. M. and Wagner, R. H. Antihemo- 
philic factor (AHF) : Some aspects of its biochemis- 
try. In: Blood Clotting Factors. Proceedings of the 
Fourth International Congress of Biochemistry, Vi- 
enna, 1958. Edited by E. Deutsch, Pergamon Press, 
New York, Vol. X, p. 1, 1959. 
18. Penick, G. D. Some factors that influence utiliza- 
tion of antihemophilic activity during clotting. 
Proc. Soc. Exp. Biol. Med. 96:277, 1957. 
19. Wagner, R. H., Brinkhous, K. M., and Penick, 
G. D. Antihemophilic factor: Some problems in its 
study. In: Hemophilia and Other Hemorrhagic 
States. Edited by K. M. Brinkhous, University of 
North Carolina Press, Chapel Hill, p. 3, 1959. 
20. Wagner, R. H., Langdell, R. D., Richardson, B. 
A., Farrell, R. a., and Brinkhous, K. M. 
Antihemophilic factor (AHF) : Plasma levels after 
administration of AHF preparations to hemophilic 
dogs. Proc. Soc. Exp. Biol. Med. 96:152, 1957. 
21. Gross, J. D., Hartmann, R. C, Graham, J. B., 
and Taylor, C. B. Splenectomy in hemophilia. 
Bull. Johns Hopkins Hosp. 100:223, 1957. 
22. Weaver, R. A., Price, R. E., and Langdell, R. 
D. Antihemophilic factor in cross-circulated nor- 
mal and hemophilic dogs. Amer. J. Physiol. 
206:335, 1964. 
23. Webster, W. P., Reddick, R. L., Roberts, H. R., 
and Penick, G. D. Release of factor VIII (anti- 
haemophilic factor) from perfused organs and tis- 
sues. Nature 213:1146, 1967. 
24. Webster, W. P., Penick, G. D., Peacock, E. E., 
and Brinkhous, K. M. Allotransplantation of 
spleen in hemophilia. N. C. Med. J. 28:505, 1967. 
25. Webster, W. P., Zukoski, C. F., Hutchin, P., 
Reddick, R. L., Mandel, S. R., and Penick, G. D. 
Plasma factor VIII synthesis and control as re- 
vealed by canine organ transplantation. Amer. J. 
Physiol. 220:1147, 1970. 
26. Barrow, E. M., and Graham, J. B. Antihemophilic 
factor activity isolated from kidneys of normal and 
hemophilic dogs. Amer. J. Physiol. 220:1020, 1971. 
27. Penick, G. D., Cronkite, E. P., Godwin, I. D., 
and Brinkhous, K. M. Plasma antihemophilic ac- 
tivity following total body irradiation. Proc. Soc. 
Exp. Biol. Med. 78:732, 1951. 
28. Brinkhous, K. M., and Penick, G. D. Some sys- 
temic alterations in clotting factors following local 
tissue injury. In: Thrombosis and Embolism. Pro- 
ceedings of the First International Conference, 
Basel, 1954. Edited by T. Koller and W. R. Merz, 
Benno Schwabe and Company, Basel, p. 428, 1955. 
29. Penick, G. D., Roberts, H. R., Webster, W. P., 
and Brinkhous, K. M. Hemorrhagic states sec- 
ondary to Intravascular clotting. Arch. Path. 
66:708, 1958. 
30. Wagner, R. H., Richardson, B. A., and Brink- 
hous, K. M. A study of the separation of fibrino- 
gen and antihemophilic factor (AHF) in canine, 
porcine, and human plasmas. Thromb. Diath. Hae- 
morrh. 1:1, 1957. 
31. Barrow, E. M., Amos, S. M., Heindel, C, and 
Graham, J. B. Separation of the antihemophilic 
factor (F. VIII) from fibrinogen with thrombin 
and manganese chloride. Proc. Soc. Exp. Biol. 
Med. 121:1001, 1966. 
32. Barrow, E. M., Amos, S., and Graham, J. B. 
Certain biochemical properties of human AHF 
(factor VIII) separated from fibrinogen with man- 
ganous chloride and thrombin. J. Lab. Clin. Med. 
68:803, 1966. 
