EHRLICH, TOSHEFF, CALDINI, KRAUSMAN, SCHRIJEN AND BRADY 
TELEPRINT OUTPITT 
571 
beat by beat 
mean values 
for 2 •econds 
systemic values 
for 2 seconds 
FLOW 
aortic coron. 
B.P. 
-> 
-> 
sya 
dla 
22.9 0.224 
27.2 0.242 
25.6 0.222 
138 555" 
139 091 
135 095 
R.A.P. 
high low 
*25.2 *0.228 *137 *096 
-00.4 — ^mrr 
-00.7 -01.8 
-00.3 -01.6 
*-00.4 *-01.5 
HR 
111 
099 
*108 
CODE 
V 
ca 
Qao.30"^ Qcor,30'^ 
MEAN 
B.P. 
MEAN 
R.A.P. 
TOTAL 
PERIPHERLAL 
RESISTANCE 
CORONARY 
RESISTANCE 
*o: 
-no. of beats 
Figure 5. — Printout. 
corder to the paper recorder. The data are 
preprocessed and fed through an interface 
into a Raytheon 709 processor with an A/D 
converter (Miniverter) . The computing system 
gives the digital values for the flows, both peaks 
of the pressures, and the cardiotachometer 
value for each heart cycle. For the successive 
two-second intervals, it provides the values for 
mean flows, mean highest and lowest pressures, 
mean heart rate, and the actual number of 
beats. For the two second intervals the system 
prints also cardiac output (Qao.SQ-^) coro- 
nary flow in the circumflex branch (Qcor.30"^) 
mean blood pressure, mean right atrial 
pressure, total peripheral resistance and coro- 
nary resistance (Figure 5) . 
With this preparation, we have investigated 
the adaptation of the cardiovascular system and 
especially of the coronary flow to exercise and 
compared it with the cardiovascular adaptation 
to food intake* and to drinking.^ We have stud- 
ied the effect of ^-blockade on the cardiovascu- 
lar system in the unanesthetised organism.® 
SUMMARY 
With the progress of our work, we gain not 
only a better understanding of the regulation of 
the cardiovascular system but also more techni- 
cal experience. Both again help us to improve 
our experimental model. 
REFERENCES 
1. Riley, R. L., and Permutt, S. Room air dis- 
infection by ultraviolet irradiation of upper air. 
Arch. Environ. Health 22:208, 1971. 
2. Gregg, D. E., Khouri, E. M., and Rayford, C. R. 
Systemic and coronary energetics in the resting un- 
anesthetized dog. Circulation Res. 16:102, 1965. 
3. Tosev (Tosheff), J., Daley, L. A., and Hilton, 
A. A method for recording intrapleural pressure in 
conscious, semi-restrained mammals. J. Appl. Phys. 
27:902, 1969. 
4. Ehrlich W., Tosheff, J., and Brady, J. V. 
Difference between adaptation of coronary flow to 
treadmill exercise and to eating. Proc. Intern. Union 
Phys. Sci. 9:158, 1971 A. 
5. Ehrlich W., Tosheff, J., Caldini, P., and Brady, 
J. V. Adaptation of cardiac output, coronary flow 
and other circulatory functions in dogs to drinking. 
Circulation 43 and 44:suppl. II, 161, 1971, B. 
6. Ehrlich W., Tosheff, J., Caldini, P., Krausman, 
D., ScHRijEN, F., Santoso, S., and Brady, J. V. 
Effect of /3-adrenergic blocking on coronary flow 
and other circulatory functions of dogs at rest and 
during adaptation to exercise. Feder. Proc. 31:640, 
1972. 
