H. L. STONE AND H. SANDLER 
597 
SUBJECT 4 
3 DAYS POST OP 
LEFT ATRIUM 12 r 
mmHg o ^ 
LEFT ATRIUM "2 
mmHg o 
288 DAYS POST OP 
RIGHT 
VENTRICLE 
mmHg q 
PULMONARY 30 
ARTERY 
mmhg 0 
LEFT 
VENTRICLE 
mmHg q 
LEFT 
VENTRICLE 
mmHg 
EKG 
EKG 
Figure 3. — Comparison of telemetry data taken 8 months apart. 
panzee 3, 288 days after surgical implantation 
of the telemetry unit. This unit continues to re- 
main functional. Analysis of Figure 6 demon- 
strates that both heart rate and pressure ap- 
pear to be similar to human levels when such 
measurements are made in the unrestrained an- 
imal. 
Figure 7 illustrates a typical tracing demon- 
strating the effects of phencyclidine (sernylan) 
anesthesia in these animals. Resting levels of 
heart rate and blood pressure were obtained 30 
minutes prior to anesthesia, followed by squeez- 
ing of the animal which produced a marked in- 
crease in heart rate and blood pressure in order 
to deliver the intramuscular medication. By 20 
minutes after injection, heart rate and blood 
pressure had returned to near baseline levels 
with little further change. Heart rate during 
anesthesia appeared slightly slower (5 to 10 
beats/minute) and left ventricular systolic 
pressure slightly lower (10 to 20 mm Hg). 
Sinus arrythmia was accentuated in all animals. 
It was concluded from these observations made 
in three animals that sernylan did not augment 
heart rate or blood pressure response compared 
to the control or resting state. 
Table I summarizes the response of seven 
animals to isoproterenol and norepinephrine in- 
fusion. All measurements were made during ser- 
nylan anesthesia. Flow increased slightly dur- 
ing isoproterenol infusion compared to resting 
values as did heart rate with little or a slight 
decrease in resulting stroke volume. Mean ar- 
terial pressure showed little change except at 
high infusion rates where there was a slight de- 
cline. Response to norepinephrine revealed no 
significant change in cardiac output and the 
presence of a significant bradycardia resulting 
in an increased stroke volume. Mean arterial 
pressure did not increase significantly except at 
higher infusion rates. 
Figure 8 illustrates the use of these units to 
obtain heart rate and left ventricular pressure 
readings (chimp 4, Group II) over a 24 hour 
period three months after surgery. The unit 
was turned on and off remotely and telemetered 
recordings obtained on magnetic tape. A diur- 
