H, L. STONE AND H. SANDLER 
Table I. — Response to Isoproterenol and Norepinephrine Infusion. 
601 
RESPONSE TO ISOPROTERENOL AND NOREPINEPHRINE 
INFUSION 
CONDITION 
CONTROL 
DOSE MAP HR 
/xg/min mm Hg beats/min 
I36±3' 
107 ±4 
CO 
l/min 
sv 
cc/beat 
3.51 ±0.20 33±2 
ISOPROTERENOL 
0.5 
1.0 
2.4 
141 ±4 
144 ±6 
151 ±8 
II4±3 
I28±I4 
128 ±12 
3.60 ±0.35 
3.60 ±0.35 
3.60 ±0.33 
3I±2 
28±2 
28±2 
NOREPINEPHRINE 
1.0 
2.0 
4.0 
I35±2 
I40±9 
146 ±3 
I02±5 
I II ±7 
99±7 
3.51 ±0.30 
3.52 ±0.4 1 
3.50±0.34 
35±3 
35±2 
35±4 
* REPRESENTS ONE STANDARD DEVIATION OF THE MEAN 
MAP= MEAN ARTERIAL PRESSURE 
HR= HEART RATE 
CO = CARDIAC OUTPUT 
SV= STROKE VOLUME 
more apparent than real and due more to emo- 
tional factors than to basic differences in species. 
It does appear that different control mecha- 
nism may be used by the chimpanzee and fur- 
ther work is required to quantify such differ- 
ences. At present, enough similarities exist to 
support use of the chimpanzee as a model for 
man. Such a model would allow for testing of 
noninvasive instrumentation techniques and for 
the use of implanted electronic packages such as 
the radiotelemetry unit used in the present 
study. This testing will allow for subsequent fu- 
ture recommendations for use of such advanced 
technology in man either directly or as part of 
other systems such as an implanted artificial 
heart. 
SUMMARY 
Cardiovascular measurements have been ob- 
tained in chimpanzees using completely im- 
plantable telemetry units. 
Recordings of intravascular pressures and 
heart rates obtained by such methods were 
lower than previously reported values obtained 
from restrained and/or anesthetized animals. 
Preliminary investigations demonstrate that 
different cardiovascular control mechanisms 
may be used by the chimpanzee compared with 
man, but further work is required to quantify 
such differences. 
Results with the implantable systems are en- 
couraging and allow for the recommendation of 
the use of such devices in man at a future date, 
