H. L. STONE AND H. SANDLER 
Table II. — Summary of Cardiovascular Data on the Chimpanzee From the Literature. 
603 
NUMBER OF 
ANIMALS 
HEART 
RATE 
BEATS/min 
CARDIAC 
OUTPUT 
iters/min 
STROKE 
VOLUME 
cc/beat 
MEAN 
ART PRES 
mmHg 
RESTING 
WEISSLER'2 
schoenfeld'^ 
HAMLIN'^ 
PRESENT STUDY 
25 
6 
9 
7 
148 ±24 
I48± 10.7 
BETA BLOCKADE 
BEFORE 
AFTER 
18 
I07±4 
148 ± 10.7 
I 16 ± 4.6* 
ALPHA BLOCKADE ( PHENOXYBENZAMININE) 
BEFORE 
AFTER 
GANGLIONIC BLOCKADE 
BEFORE 
AFTER 
90*' TILT '2 
BEFORE 
AFTER 
I 3 
152 ± 15 
176 ± 19 
147 ± 8.2 
II4± 16.6=* 
145 
166 
8 
8 
176 ± 17 
180 ± 15 
90° TILT WITH ALPHA BLOCKADE 
BEFORE WITH 
ALPHA BLOCKADE 
AFTER WITH 
ALPHA BLOCKADE 
*SIGNIFICANT DIFFERENCE, p <0.0I 
11. Franklin, D. L., and Van Citters, R. L. Blood 
flow in mesenteric artery of chimpanzee, monitored 
via radiotelemetry. Aero. Med. 38:926-931, 1967. 
12. Parratt, J. R. The effects of histamine on the my- 
ocardial circulation. Eur. J. Pharm. 6:203-208, 
1969. 
13. Simmons, R. L., Ducker, T. B., and Anderson, 
R. W. Pathogenesis of pulmonary edema following 
head trauma: An experimental study. J. Trauma 
8:800-811, 1968. 
14. Fryer, T. B., Sandler, H., and Datnow, B. A 
multichannel implantable telemetry system. Med. 
Res. Eng. 8:9-15, 1969. 
15. Sandler, H., Stone, H. L., and Fryer, T. B. The 
use of implantable telemetry systems for study of 
3.07 ±0.36 
3.72 ±0.96 
3.24±0.55 
3.51 ±0.20 
3.72±0.96 
2.79±0.58 
21 ±4 
25±5.9 
3.52 
3.42 
3.94 
2.56 
3. 
2, 
±0.57 
± I .25 
±0.61 
±0.85* 
.17 
66 
3.54+ 1 .2 
2.41 ±0.83' 
33±2 
25± 5.9 
24 ±3.6 
23±4.3 
I9±5.7 
27±6.5 
22±7.6' 
23 
I 7 
20 ±6 
I4±4' 
1 34 ±24 
1 36 ±24 
I36±3 
I36±24 
I30±28 
144 ± 20 
106 ±29* 
146 ±27 
98 ±24' 
128 
125 
104 ±22 
86 ± I 3' 
cardiovascular phenomena. Circ. Res. (in press) 
1972. 
16. Sandler, H., Fryer, T. B., Westbrook, R. M., 
and Konigsberg, E. Miniature implantable accel- 
erometers. In: Implanted Cardiovascular Instru- 
mentation. E. P. McCutcheon, Ed. Academic Press, 
Inc. N.Y. (in press) 1972. 
17. Linebarger, R. N., Lim, R. S., Sandler, H., and 
Fryer, T. B. Real time computer measurement of 
heart dimensions from implanted accelerometers. 
Proc. Conf. Eng. Med. Biol. 9:31.2, 1967. 
18. Stone, H. L., Sandler, H., Fryer, T. B. 
Cardiovascular function in the chimpanzee studied 
by chronic instrumentation techniques. In: The 
Chimpanzee. Vol. V. G. Bourne, Ed. S. Karger, 
Switzerland (in press) 1972. 
