J. D. BAGGOT AND L. E. DAVIS 
697 
Figure 3. — The percent of dose of amphetamine, p-hydroxyamphetamine and its conjugates in cumulative urine (24 
hours in all species except cats, 48 hours) of different species. The number in parentheses is the number of 
animals studied in the species. 
excretion of unchanged amphetamine was low 
in all species examined (dog, swine, rat,^^ and 
man^s) . 
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Table VII. — Plasma Protein Binding of Amphetamine 
in Dogs 
Variable 
% Bound Amphetamine 
in vitro 
in vivo* 
Amphetamine cone 
135 ng ml-i 
100-150 ng ml-i 
Mean 
27.1 
23.7 
n 
17 
15 
S.E 
1.5 
1.1 
I student's "t" test: n.s. (p > 0.05) 
• Experimental subjects were 7 healthy and 8 nephrectomized 
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