L. E. DAVIS, C. A. DAVIS AND J. D. BAGGOT 
725 
CHLORAMPHENICOL - ORAL 
12-, 
0 1 2 3 4 5 6 7 8 
— — CAT 
<— — • DOG 
SWINE 
PONY 
TIME IN HOURS 
Figure 7. — Concentrations of chloramphenicol in plasma following the oral administration of chloramphenicol (22 
mg/kg) . Each point represents the mean value from eight animals. Chloramphenicol was not detectable in the 
plasma of goats following oral administration. 
found after oral administration. This substanti- 
ates the finding of Theodorides et al.^^ that 
chloramphenicol is reduced to aryl amines by 
the ruminal microflora. 
Figure 8 illustrates similar information fol- 
lowing intramuscular injection of chloramphen- 
icol (10 mg/lb). Peak plasma concentrations 
were obtained by one hour or less in all species. 
CHLORAMPHENICOL IM 
E 
cn 
TIHE IN HOURS 
Figure 8. — Concentrations of chloramphenicol in plasma following the intramuscular injection of chloramphenicol 
(22 mg/kg.). Each point represents the mean value from eight animals. 
