D. C. SAWYER, E. I. EGER, II AND W. V. LUMB 
761 
Table I. — Cardiovascular and Blood Values Record 
From Nine Miniature Swine (32 ±i kg) Before and 
During Halothane Anesthesia 
Preanesthesia % 
control values Anesthesia change 
CO 
(ml/min) 3244 ± 668 1600 ± 235 —50 
SV 
(ml) 28 ± 6 14 ± 2 -50 
Stroke Work 
(mm Kg .1) 2.91± 1.06 0.89± .24 —69 
MAP 
(mm Hg) 106 ± 30 62 ± 8 -41 
HR 
(beats/min) 118 ± 18 119 ±17 0 
PVR 
(mm Hg/l/min) _ . . 36 ± 9 41 ± 9 +14 
Hot. 
(%) - - 40 ± 3 31 ± 3 —22 
pH 7.49± .02 7.43± .03 
Paco2 
(mm Hg) 34.2 ± 3.3 46.5 ± 5.8 
Bid. anes. cone. 
(mg/100 ml) 0 20.1 ± 1.6 
Calc. alv. cone. 
(%) - 0 1.1 
Table III. — Cardiovascular and Blood Values Recorded 
From Nine Miniature Swine (32.7 ± 3 kg) Before and 
During Thiamylal Anesthesia 
Preanesthesia % 
control values Anesthesia change 
CO 
(ml/min) 3022 ± 686 1900 ± 466 —38 
SV 
(ml) 26 ± 5 15 ± 5 —41 
Stroke Work 
(mm Hg .1) 3.02± .75 2.42± .94 -20 
MAP 
(mm Hg) 114 ± 13 154 ± 20 +34 
HR 
(beats/min) 115 ± 17 127 ±28 +9 
PVR 
(mm Hg/l/min) 40 ± 10 87 ± 25 +122 
Hct. 
(%) 39 ± 4 33 ± 4 —16 
pH 7.48± .03 7.45± .06 
Paco2 
(mm Hg) 34 ± 3 41 ± 6 
Bid. anes. cone. 
(mg/100 ml) 0 3.6 ± 0.5 
± = Standai'd deviation 
± = Standard deviation 
anesthesia, variables returned to control levels 
in 2 hours. Pigs w^ere usually able to stand 
within 1 hour and eat within 3 hours. After 
methoxyflurane anesthesia, variables did not re- 
turn to control levels for 24-96 hours postanes- 
thesia and animals appeared mildly depressed 
for 24 hours. After pentobarbital anesthesia, 
Table II. — Cardiovascular and Blood Values Recorded 
From Ten Miniature Swine (32.7 ± 3 kg) Before and 
During Methoxyflurane Anesthesia 
Preanesthesia % 
control values Anesthesia change 
CO 
(ml/min) 3083 ± 600 1898 ± 678 —39 
SV 
(ml) 27 ± 4 13 ± 3 —48 
Stroke Work 
(mm Hg .2) 3.09± 0.54 1.05± 0.30 —66 
MAP 
(mm Hg) 114 ± 15 82 ± 10 -29 
HR 
(beats/min) 113 ± 18 140 ± 21 +20 
PVR 
(mm Hg/l/min) 39 ± 9 49 ± 15 +21 
Hct. 
(%) 42 ± .04 36 ± 3 
pH 7.46± .04 7.42± .05 
Paco2 
(mm Hg) 35.1 ± 2.8 51.4 ± 4.5 
Bid. anes. cone. 
(mg/100 ml) 0 18.6 ± 0.7 
Calc. alv. cone. 
(%) 0 0.22 
variables did not return to control levels for 
96-144 hours. Pigs became ambulatory 5 hours 
after anesthetic administration had ceased and 
were ataxic for over 24 hours. The same was 
true after thiamylal anesthesia, but even 24 
hours postanesthesia, animals were reluctant to 
stand and would not eat for 36-48 hours. 
Detailed results of anesthetic metabolism 
have been published.^ " " From investigations 
following halothane (Table V)^ and fluroxene 
Table IV. — Cardiovascular and Blood Values Recorded 
From Ten Miniature Swine (32.7 ± 3 kg) Before and 
During Pentobarbital Anesthesia 
Preanesthesia % 
control values Anesthesia change 
CO 
(ml/min) 3237 ± 675 1914 ± 367 —41 
SV 
(ml) 28 ± 4 16 ± 3 —45 
Stroke Work 
(mm Hg .1) 3.32± .77 1.99± .52 —40 
MAP 
(mm Hg) 119 ± 21 128 ± 17 +8 
HR 
(beats/min) 117 ± 18 123 ±8 +8 
PVR 
(mm Hg/l/min) 38 ± 9 70 ± 16 +86 
Hct. 
(%) 40 ± 3 33 ± 4 —17 
pH 7.50± 0.03 7.38± .06 
Paco2 
(mm Hg) 33 ± 3 52 ± 11 
Bid. anes. cone. 
(mg/100 ml) 0 4.2 ± 0.9 
± = Standard deviation 
± = Standard deviation 
