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DISCUSSION 
BENJAMIN T. Cole, University of South 
Carolina, Columbia : I may have missed this in 
your introduction, but were the 405 or more 
aortas taken from animals which simply died? 
In other words, you don't correlate the presence , 
of the lesion with death or the age of the ani- 
mal ? Is there any correlation with your data be- ; 
tween age ? j 
The reason I bring this up is that there have 
been studies made in human aortas by someone 
at the Medical School at LSU where aortas 
were taken and a similar study done. His sam- 
ple covered only decedents who had no history 
of cardiovascular disease. He found the interest- 
ing correlation that lesions were present in pre- 
pubertal humans. They seemed not to be so pro- 
lific during the period of active sexual life, 
(normally from puberty to menopause) but ap- 
peared again in aging persons. So my original 
two questions relate to that problem. 
Dr. Stout : I didn't mention that, and I want 
to apologize, especially to the projectionist, for 
racing through the presentation. We did more or 
less consecutive autopsies for this five year 
period, so there was no obvious selection. In 
general, the lesions were positively correlated 
with advancing age, but not with sex. We could 
not correlate the lesions with any disease process 
simply because there were too many different 
species involved, and too many different causes 
of death. Also, in a number of cases, we could 
not determine the exact cause of death. 
Dr. Cole : That answers my question. The in- 
teresting aspect of the work in human aortas 
was the possible endocrine factor in this normal 
event of clot formation which never becomes ex- 
cessive enough to cause any clinical abnormal- 
ity. 
Wilbur P. McNulty, Oregon Primate Cen- 
ter, Beaverton, Oregon: Did the lesions corre- 
late at all with length of time in captivity inde- 
pendent from age ? 
Dr. Stout : Our records were not as complete 
as those at the Philadelphia Zoo, so that I can't 
answer the question. We did try to make this 
determination in birds, but were unable to see 
any definite correlation between the length of 
time in captivity and the severity of arterioscle- 
rosis. 
Keith McCullagh, Cleveland Clinic: I 
would like to make a comment and a question. 
The comment regards Dr. Cole's question con- 
cerning age and spontaneous atherosclerosis. I 
did a study in East Africa with about the same 
