D. D. JOEL AND E. P. CRONKITE 
897 
cepts particularly in the field of transplantation. 
In experimental animals ECIB alone has been 
shown to substantially extend the survival of 
renal allografts in the absence of any apparent 
toxic effects. More importantly, studies with 
skin allografts suggest than ECIB may act 
synergistically with reduced doses of immuno- 
suppressive drugs. In animals so treated no 
significant reduction in antibody synthesis to 
tetanus toxoid was observed. In clinical renal 
transplantation ECIB may, therefore, allow a 
reduction in the dose of immunosuppressive 
drugs which themselves can cause widespread 
destruction effects on normal tissues. Recent 
reports in a limited number of patients indicate 
this is indeed true.^^ Further experimentation 
with ECIB and ECIL is clearly indicated. 
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