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DISCUSSION 
McClellan G. Blair, ARCO Nuclear Co. : I 
have a question regarding the area surround- 
ing the Implants. What was the nature of the 
effect of the capsule on the surrounding tissue? 
Dr. Molokhia: Some of the dogs which 
survived at 14 and 25 months were subjected 
to a detailed histological examination. On exam- 
ination, the area of the capsule was surrounded 
for the first few millimeters by degenerating 
acellular tissue. Then, it was dense fibrous tis- 
sue. The tissue was examined by Doctor Shields 
Warren, Professor of Radiation Pathology 
in Harvard Medical School, and he could iden- 
tify some large fibroblasts, which he called 
radiation fibroblasts. But there was no evidence 
of any neoplasia or tumors anywhere in the dogs 
at 25 months. 
Dr. Blair : Were there any neoplasia or any- 
thing like this formed on the interior of the 
tubes used? 
Dr. Molokhia: No viable cells could be seen. 
Dr. Blair: What was the temperature gra- 
dient between the blood and the body of the 
capsule? 
Dr. Molokhia : Between 43 and 37 C. 
Dr. Blair : I think you reported it as an in- 
crease in the temperature of the blood cells fol- 
lowing the implantation? 
Dr. Molokhia: No, I'm speaking about the 
lung further off. Once the animals had recov- 
ered from the surgical intervention, the tem- 
peratures dropped to normal. 
Dr. Blair : But the temperature of the sur- 
rounding tissue would have to be somewhat 
higher than the temperature of the blood. 
Dr. Molokhia : Right. That was 41 to 42 C, 
as compared with the normal. 
