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DISCUSSION 
Chairman Joel : Are there any questions or 
comments for Dr. Ragan and his presentation? 
Yes? 
Francis L. Earl, Food and Drug Adminis- 
tration: (Inaudible) 
Dr. Ragan : No, I didn't give an explanation 
for it. Statistically it was not different, and 
there are a large number of animals involved in 
this particular analysis at that dose level. At 
some of the higher dose levels, there are fewer 
numbers, but they were not significant. 
Dr. Earl: But, on j-our slide, you infiltrate 
them. Is this a leukocji^ic infiltration that makes 
this appearance so malignant? 
Dr. Ragan : No. It depends on the cell types 
of our leukemia. If it's a granulocytic leukemia, 
we get that infiltrated with the neoplastic gran- 
