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ACKNOWLEDGMENT 
The author is grateful to his colleagues of the 
Comparative Cardiovascular Studies Unit, Uni- 
versity of Pennsylvania, for their past and 
continuing contributions to the studies described 
in this paper. He is particularly indebted to Dr. 
D. K. Detweiler, Dr. R. L. Pyle, Dr. J. W. 
Buchanan, Dr. D. H. Knight, and Dr. E. N. 
Moore. 
DISCUSSION 
Chairman Pierce: Are there any questions 
for Dr. Patterson? 
Dr. Patterson, w^e are all aware of your valu- 
able resource, of not only congenital patent duc- 
tus, but other lesions as well. What is the prac- 
ticality of other laboratories developing colonies 
of such animals? 
Dr. Patterson : Well, certainly, our experi- 
ments which yielded from 10 to 90% affected 
offspring, show that it is quite feasible to pro- 
duce animals with cardiovascular defects for a 
variety of different purposes. One intriguing 
