1026 
ANIMAL RESOURCES 
It should be noted that the overwhelming ma- 
jority of those reporting would like to see this 
service continued, i.e., 49 positive responses to 
question #6 and only 2 negative responses. The 
2 individuals who responded negatively to that 
question offered the following comments under 
question #8 : 
1. "We have used your services infre- 
quently and therefore cannot justify 
continued financial support for this op- 
eration, regardless of the source." 
2. "I decided a few years ago to give up 
all animal work. The diagnostic service 
you refer to was peripheral to my major 
concern. However, it did not achieve a 
real integration with my interests in the 
animals. It seemed to be a far more de- 
tailed examination than was appropri- 
ate in most cases." 
In contrast to these negative comments, are 
the following as examples of comments from 
researchers who responded positively to ques- 
tion #6 : 
1. "Rescue of experiments by early diag- 
nosis and treatment of valuable, 2-3 
chronic animals is both money-saving 
and reassuring." 
2. "Without your thorough and expedi- 
tious promptness, this laboratory could 
have experienced a disaster." 
3. "The service has been most thorough in 
its workup, and very prompt in giving 
a final report." 
4. "I consider this a most important serv- 
ice ; and would further like to state that 
the quality of this service has been 
superior." 
5. "Your department and the entire vi- 
varium staff have been of tremendous 
help to me in my research efforts. Many 
thanks." 
6. "Service was prompt. The presence of 
the diagnostic lab offers a readily avail- 
able information source much needed in 
the area." 
B. Research 
Research activities carried out with the sup- 
port of the diagnostic laboratory grant are of 2 
basic types : 1 ) investigations to further eluci- 
date the etiology and pathogenesis of naturally 
occurring diseases of laboratory animals and 
2) preliminary studies on certain diseases of 
animals in an attempt to characterize their po- 
tential as animal models for studying an analo- 
gous disease in man. Both of these research ob- 
jectives are in accord with the responsibilities 
of a resource investigative laboratory as defined 
by McPherson.^ Some of our research projects 
were directed at major problems of laboratory 
animals that did not necessarily originate 
through our diagnostic laboratory, e.g., canine 
viral respiratory disease. In addition, some re- 
lated research projects were funded by other 
grant monies although the actual work was car- 
ried out within the facilities and by the person- 
nel of the diagnostic laboratory. 
Examples of research topics supported in 
large part by the diagnostic laboratory grant 
include : 
1. Canine adenoviral pneumonia: 
Studies have been carried out on the 
pathogenesis of pneumonia in young 
dogs exposed to a canine adenovirus 
which has been shown to be involved in 
respiratory disease of dogs in institu- 
tional facilities.*''^ Sero-negative dogs 
have been exposed by both intratracheal 
deposition of virus containing fluids and 
controlled aerosols of the virus. Se- 
quential studies have been done on the 
development of lesions in correlation 
with the clinical signs of disease. Histo- 
pathologic, virus-isolation, serologic, 
and immunofluorescent procedures have 
been used to evaluate the changes. Pre- 
liminary results of this study were pre- 
sented at the 52nd annual meeting of 
the Conference of Research Workers in 
Animal Diseases held in Chicago, Illi- 
nois, November 28-30, 1971. A manu- 
script to report the results in detail is 
in preparation. 
2. Comparative pathology and host speci- 
ficity of a poxvirus isolated from spar- 
rows : 
The pathologic response to experi- 
mental infection with a poxvirus iso- 
lated from sparrows was studied in 3 
