A. M. JONAS 
1059 
70 r 
^ "Si 60 h 
ir 3: 
— 40 h 
>- UJ 
oc q: 30 
<i =) 
o CO 20 
a. 
10 
9204 
TOXOCARA 
pH « 7. 44 
PO2 = 121 
pCO- = 13.5 
J L 
_L 
J L 
J 
.1 .2 .3 .4 .5 .6 .7 .8 .9 1.0 1.1 
CARDIAC OUTPUT (L/min) 
Figure 4. — Cat inoculated with 1,000 embryonated eggs 
of Toxocara cati for 20 consecutive days and then 
studied 4 days later. This pulmonary artery pres- 
sure/flow curve demonstrates marked elevation as com- 
pared with control data. Lower curve is from a con- 
trol animal. 
0 = Plow rate of 125 ml/kg/min. 
1 = Range within ± 1 s.D. for normal control data 
calculated at a flow rate of 125 ml/kg/min. 
disease of hamsters referred to variously as 
"wet tail," proliferative ileitis^^ and enzootic 
intestinal adenocarcinoma. Our original 
publication^^ suggested the terminal event in 
this intestinal disease should be considered a 
neoplastic invasion. Recently, tv^o cases of this 
disease have been studied^^ with apparent neo- 
.E 140 r 
< - 120 - 
o o. 100 - 
to 3: 
>| 80 - 
§ 60 
o < 40 
ZO- 
9204 
TOXOCARA 
pH = 7.44 
PO2 = 121 
PCO2 = 13.5 
.1 .2 .3 .4 .5 .6 .7 .8 .9 1.0 1.1 
CARDIAC OUTPUT (L/min) 
Figure 5. — This pulmonary vascular resistance/ flow 
curve of same cat in Figure 4 demonstrates a marked 
increase in PVR. Vascular lesions were minimal in 
this case, possibly indicating an early vasomotor 
component. 
0 = Flow rate of 125 ml/kg/min. 
1 = Range within ± 1 s.D. for normal control data 
calculated at a flow rate of 125 ml/kg/min. 
plastic lesions in their livers. These hepatic le- 
sions were necrotic except for viable acinar 
structures at their borders. The question 
whether these acini are derived from bile ducts 
or are indeed metastatic from the intestine has 
not been answered. Heslop^® reported on a dis- 
ease outbreak of intestinal colonic adenocarci- 
noma in the rat, which, in our opinion, has 
marked similarities to the hamster disease. 
Both of these examples may be unique models 
for future study of intestinal cancer or at least 
remarkable proliferative disorders. The reac- 
tive features associated with invading "tumor" 
tissue in the Hamster's intestinal wall suggests 
a possible role for immunologic reactivity 
against tumor antigens in the natural history of 
the disease. 
DISCUSSION/SUMMARY 
Many other diseases have been studied in our 
laboratory,i^"2i but the purpose of this paper 
is to emphasize the many-faceted approaches 
and rewards that the veterinary diagnostic and 
investigative laboratory can achieve in its serv- 
ice and research roles within an institutional 
setting involved with "Animals in Medical Re- 
search." 
REFERENCES 
1. Jonas, A. Laboratory animal facilities. J. Am. Vet. 
Med. Assoc., 146:600-606, 1965. 
2. Jonas, A. M., and Bhatt, P. N. A spontaneous 
outbreak of sendai virus causing high morbidity 
and mortality in suckling mice. Manuscript in prep- 
aration. 
3. Appell, L. H., Kovatch, R. M., Reddecliff, J. 
N., and Gerone, P. J. Pathogenesis of sendai virus 
infection in mice. Am. J. Vet. Res. 32:1835-1841, 
1971. 
4. Parker, J. C, Tennant, R. W., Ward, T. G., and 
Rowe, W. T. Enzootic sendai virus infections in 
mouse breeder colonies within the United States. 
Sci. 13:936-938, 1964. 
5. Hsiung, G. D., and Kaplow, L. S. Herpeslike 
virus isolated from spontaneously degenerated tis- 
sue culture derived from leukemia susceptible 
guinea pigs. J. Virol. 3:355-357, 1969. 
6. Bhatt, P. N., Percy, D. H., Craft, J. L. and 
Jonas, A. M. Isolation and characterization of a 
Herpeslike (Hsiung-Kaplow) virus from guinea 
pigs. J. Inf. Diseases, 132:178-189, 1971. 
