FRANKLIN, VATNER, HIGGINS, PATRICK, KEMPER AND VAN CITTERS 
SITS 
1131 
i CORONARY BLOOD 
FLOW VELOCITY 
cm/sec 
MEAN FLOW 
ml/min 
AORTIC BLOOD 
PRESSURE 
mmHg 
MEAN PRESSURE 
mmHg 
HEART RATE 
beats/min 
MEAN CORONARY 
RESISTANCE 
mmHg / ml/min 
lOOn 
POSTURAL 
I- CHANGES ^^'-'^4 SITS RUNNING a JUMPING^ SITS 
I- -H 
25 sec 
Figure 5. — A segment of recordings showing the response to a variety of spontaneous activities in a baboon such 
as the one shown in Figure 4. The phasic and mean values for coronary flow and arterial pressure are 
shown along with computed heart rate and resistance. (Reprinted with permission from Am. J. Physiol. 
221:1396, 1971). 
14. Harpuder, K., Lowenthal, M., and Blatt, S. 
Peripheral and visceral vascular effects of exercise 
in the erect position. J. Appl. Physiol. 11:185, 1957. 
15. Wade, 0. L., Combes, B., Childs, A. W., Wheeler, 
H. 0., CouRNAND, A., and Bradley, S. E. The effect 
of exercise on the splanchnic blood flow and 
splanchnic blood volume in normal man. Clin. Sci. 
15:457, 1956. 
16. RowELL, L. B., Blackmon, J. R., and Bruce, R. A. 
Indocyanine green clearance and estimated hepatic 
blood flow during mild to maximal exercise in up- 
right man. J. Clin Invest. 43:1677, 1964. 
17. Wade, 0. L., and Bishop, J. M. The distribution of 
cardiac output in normal subjects during exercise. 
In Cardiac Output and Regional Blood Flow. Black- 
well Scientific Publication, Oxford. 95. 1962. 
18. Best, C. H., and Taylor, N. B. The output of the 
heart and the regulation of its action. In The 
Physiological Basis of Medical Practice. The Wil- 
liams & Wilkins Co., Baltimore. 302, 1961. 
19. Herrick, J. F., Grindlay, J. H., Baldes, E. J., 
and Mann, F. C. Effect of exercise on the blood 
flow in the superior mesenteric, renal and common 
iliac arteries. Amer. J. Physiol. 128:338, 1939. 
20. RusHMER, R. F., Franklin, D. L., Van Citters, 
R. L., and Smith, 0. A. Changes in peripheral 
blood flow distribution in healthy dogs. Circ. Res. 
9:675, 1961. 
21. Van Citters, R. L., and Franklin, D. L. Cardio- 
vascular performance of Alaska sled dogs during 
exercise. Circ. Res. 24:33, 1969. 
22. Vatner, S. F., Higgins, C. B., Franklin, D., and 
Braunwald, E. Role of tachycardia in mediating 
the coronary hemodynamic response to severe exer- 
cise. J. Appl. Physiol. 32 : 380-385, 1972. 
23. Higgins, C. B., Vatner, S. F., Franklin, D., and 
Braunwald, E. The effects of experimentally pro- 
duced heart failure on the peripheral vascular 
response to exercise. Circ. Res. 31 : 186-194, 1972. 
24. Vatner, S. F., Higgins, C. B., and Franklin, D. 
Regional circulatory adjustments to moderate and 
severe chronic anemia in conscious dogs at rest and 
during exercise. Circ. Res. 30 : 731-740, 1972. 
25. Vatner, S. F., Higgins, C. B., Millard, R. W., and 
Franklin, D. Unpublished observations. 
