K. T. WEBER, J. S. JANICKI, A. A. WALKER AND B, H. DENNISON 
1267 
EKG 
LVP 
MM HO 
A P 
MM HG 
C B F 
'lliilii^ A A A iiili^ An,/ 
IS ^■ 
8.1 
1 
80 SEC 
CIRCUMFLEX OCCLUSION 
Figure 6. — Continuous monitoring during acute circumflex occlusion. Displayed are electrocardiogram (EKG) ; 
left ventricular pressure (LVP) ; arterial pressure (AP) ; left main coronary flow (CBF) ; and aortic flow 
(AoQ). 
ligation by treatment with massive doses of insulin. 
Cardiovas. Res. 5:48-53, 1971. 
13. Weber, K. T., Heck, F. J., Dennison, B. H., 
Rean, A. K., and Harmison, L. T. Intra-aortic 
balloon pumping: The eff'ects of inflation duration 
in unanesthetized calves. Supplement II to Circ. 43 
and 44:11-238, 1971. 
DISCUSSION 
H. Clark, Palo Alto: I was just curious if 
that was glucagon free insulin that you used. 
Dr. Weber : No, sir, it was not. We are cur- 
rently in the process of evaluating the effect of 
glucagon-free insulin alone. 
Dr. Clark : I would suspect from the rather 
large doses of insulin that you may have, it's like- 
ly you may have a little bit of glucagon effect. 
Dr. Weber : Yes, I'm sure v^e do, and we do 
see an inotropic effect that is reminiscent of 
that of glucagon. How^ever, the electrical 
changes or arrhythmia control that accompany 
the insulin are not that of glucagon unless you 
have information to the contrary. 
S. Cassin, University of Florida, Gaines- 
ville: Do you have any idea what the larg- 
est dose of microspheres is and what this 
represents in total number of spheres? 
Dr. Weber: No, I'm sorry, I don't. I also 
have no idea as to the quantity of myocardium 
that is damaged v^^ith these doses, but it is a 
diffuse process involving the entire left ventric- 
ular myocardium. 
C. G. La Farge, Children's Hospital, 
Boston : Just a brief comment about the balloon 
