C i4§f ) 
V. An Account of a ^ookj, entitukd^ Confilium ^Etio - 
logicum De Cafu quodam Epileptico : Quo re- 
fpondctur Epiftolae DodifiT. Viri Thom.^ Hobarc^ 
M.D, Annexa difquificione de Perfpirationis In- 
fenfibilis Materia, & Peragend^e ratione. Aiithore 
Gulieimo Cole.^ M.D- Coli.Med. Land. Socio. 
THe Author having received a very curious Letter from Dr Ho- 
bart o? Cambridge^ containing a remarkable Cafe of a Perfon, 
newly become his Patient, affliSed for four years with an Epiiepjy^ 
on which he requefts his opinion, and h/s thoughts concerning the 
method of cure, to be ufed in it ^ adding withal feveral fhort, but 
material, remarks concerning the Inefficacy of Specijicks^ the inter- 
polate ufe of Purgatives according to T>r Syienham^ gcc. Endea- 
vours, in complyance with his defire, firft, to give an account of 
the particular Seat of the Matter of Epilepfies in the Brain ^ then 
to confider the Method of Cure^ and to anfWer feveral queftions and 
doubts hinted in the Letter. The Seat he takes (from reafons he 
alledges) to be the innermoft region of the G7r//V^,part of it, near 
where it turns into the Medullar^ at which place he thinks (accord* 
ing to an Hypothefis hs heretofore delivered) the Nutritious Juice, 
newly feparated from the Blood, but happening to be fomevvliat 
more grofs than ufual, meets with a check, in its progrefs, on the 
account of the natural coarSlation of. the VeffeLs here at their paf- 
fing into the Medullar ^ fo that, the protrulion being continual, it 
muft undergo fome congeffion, and ;n fome meafure diftend this 
Repofitory », whereby being of an active nature, it gradually be- 
comes maturated into a Ferment This, when it has arrived at a 
certain degree of Acrimony, ( partly thence, partly from rhe di- 
ftention it makes) breaks forth into the continued channels of the 
Medullar part, and there, by vellicating them, begins thofe ter- 
rible Symptoms of the Epilepfy. This matter, as well when lb 
depraved, as naturally, murt go forward along rhe tracts of the 
Nerves and Fibres-, fince it has no other- way of excluSon, in which 
progrefs it may be prefumed to produce variety of Symptoms, on 
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