4 6 
Scientific Proceedings (41). 
<p == in grm. blood in ten minutes for left hand, i. e. y 6.5 
grm. per minute per 100 c.c. of hand. 
<p = 306 grm. blood in ten minutes for right hand, i. e., 14.5 
grm. per minute per 100 c.c. of hand. 
Conclusion. — In the hand whose lower motor neurones were 
not involved in the lesion producing the paralytic condition the 
blood-flow per unit volume of hand substance is scarcely inferior 
to that in the normal hand. 
In the hand a lesion in whose lower motor neurones is respon- 
sible for the paralysis, the blood flow per unit volume of hand 
substance is 2^ times less than in the normal hand. The dif- 
ference in the amount and condition of the muscular tissue is one 
important factor in causing the difference in blood flow in the 
two conditions. 
26 (55i) 
Edema formation in guinea pigs in chronic experimental 
uranium nephritis. 
By ERNEST 0. DICKSON. 
{From the Pathological Laboratory of Cooper Medical College.] 
In a series of experiments performed on guinea pigs during 
the past two years, with the purpose of confirming the findings in 
experimental chronic nephritis which I have previously reported, 1 
some interesting observations in edema formation have been made. 
Twenty-one animals received subcutaneous injections of an 
aqueous solution of uranium nitrate, as follows: six received 
numerous injections of 0.5 m.grms. at frequent intervals; eight 
received several injections of 5 m.grms. at longer and irregular 
intervals; and seven received one or more injections of 10 to 15 
m.grms. Four animals died within two weeks after the first 
injection, and can be excluded from the chronic nephritis series. 
The remaining seventeen survived for from three to twenty-three 
months after the first injection, and all showed kidney lesions of 
a chronic nature, similar to those which I have previously de- 
scribed. 
In Group I, which received the numerous small doses, two 
1 The Archives of Internal Medicine, June, 1909, vol. iii, No. 5. 
