4 8 
Scientific Proceedings (41). 
month showed no edema, and of the ten which lived for longer than 
eight months, nine showed definite, and in some cases, marked 
edema. In four of the nine cases there was marked subcutaneous 
edema, which in three cases was associated with effusion into the 
serous cavities. All of the cases of subcutaneous edema occurred 
in Groups II and III, where relatively large doses of the drug were 
administered. 
In none of the cases was any attempt made to induce edema 
formation by forcing water. The animals were fed upon a mixed 
diet in which was a plenty of greens, and they obtained all their 
water from the green food. Since death occurred in every case 
but one within eleven days after the last injection, and during 
the resulting acute intoxication, it would seem that the edema was 
a true renal edema, and not due to stasis resulting from a broken 
down heart. There can be little doubt that the prolonged action 
of the uranium nitrate upon the blood vascular system had so 
damaged it, that it was unable to withstand the strain of the 
plethora which was produced by the inability of the kidney to 
excrete water during the terminal attack of acute nephritis. 
27 (552) 
The action of infundibulin upon the mammary secretion. 
By ISAAC OTT and JOHN C. SCOTT. 
[From the Physiological Laboratory, Medico- Chirurgical College of 
Philadelphia.] 
In the goat we have found in the early nursing period that 
infundibulin (the active principle of the posterior part of the 
hypophysis), when injected into the vein of the ear, rapidly and 
greatly increased the secretion of milk. The nipple had a cannula 
inserted into it, and a water aspirator produced the suction 
necessary to empty the udder. The milk before and after the 
injection was caught in a graduated flask and measured every five 
minutes. The following experiment will given an idea of the 
activity of the infundibulin : 
Goat — Right Nipple. 
2.25 P.M. 
2 -30 " 4 drops milk. 
2.35 " 5 " 
