Glycogenolytic Strength of Blood Serum. 21 
from I c.c. to 5 c.c. By thus varying the conditions, chances of 
error are greatly eliminated. Controls were run in all the experi- 
ments except in some of the estimations of experiments 3 and 8 in 
which there was not sufficient serum or lymph for this purpose. 
Table I gives the results of these experiments. 
Consideration of Results. — In experiments IV and VIII there 
was no evidence of increase of glycogenase during stimulation of 
the splanchnic nerve. There was a slight increase in the ferment 
contained in the femoral blood after the stimulation in experiments 
VIII and IX, but, since this was 60-80 minutes after the stimu- 
lation had been removed, the increase cannot be due to the stimu- 
lation. In experiment III there was a slight increase both in the 
pancreatic vein and in the lymph immediately after the stimula- 
tion. In experiment VI there was an increase in the lymph and 
in the femoral artery blood during the stimulation. The only ex- 
periment, therefore, in which splanchnic stimulation certainly 
caused a rise in glycogenase was No. VI. The increase occurred 
primarily in the lymph and secondarily in the systemic blood. 
It fell off in both after the stimulation was removed. We are not 
in a position at present to determine whether this result is of any 
importance in the metabolism of carbohydrates in the animal 
body, but we do not believe that it has any relationship to the 
increased glycogenolysis which occurs in the liver as a result of 
stimulation of the splanchnic nerve. Did it have this relationship 
we should expect the increase in glycogenase to occur in the blood 
of the pancreatico-duodenal vein rather than in the lymph. 
