Thyroid Insufficiency. 
5 
Various operations were performed with a view to preventing 
an early "callous" formation, and inducing a rapid growth of 
periosteum and thereby permitting the growth of the other tissues. 
Most of the legs operated in this way grew distinct "buds" or 
cones or various malformed or not fully developed limbs. 
This incomplete or teratologic regeneration seemed to be due 
to the influence of a second factor, namely the rate and manner of 
growth of the connective tissue. This tissue is differentiated 
quite early, grows about and soon completely surrounds the 
developing embryonic tissues, apparently preventing their further 
growth. 
Experiments are now under way, to control not only the growth 
of the periosteum but also this connective tissue, so as to permit, 
if possible, the complete regeneration of the leg. 
3 (528) 
Does the pituitary body compensate for thyroid insufficiency ? 
By SUTHERLAND SIMPSON and ANDREW HUNTER. 
From the Department of Physiology and Biochemistry of the Cornell 
University Medical College, Ithaca, N. Y.] 
Exactly one year ago we submitted to this society the results 
of some experiments performed on sheep with a view to throw 
light on the question of the vicarious relationship between the 
thyroid and pituitary glands. Herring and others had found 
histological appearances in the pituitary of thyreodectomized 
animals which suggested a compensatory hypertrophy in that 
gland, and our object was to determine whether iodine appears 
in the pituitary of animals from which the thyroid gland has 
been removed. 
The operation of total thyroid extirpation was performed on 
ten sheep, and the pituitaries removed at death were found to 
contain no iodine, but we felt at the time that our results were 
not conclusive, and for three reasons — first, five of our sheep died 
early (six to thirty-two days) from a parasitic infection quite 
unassociated with the operation; second, the available amount of 
dried pituitary from the ten sheep (1.02 gram) was only sufficient 
