68 
Scientific Proceedings (42). 
39 (564) 
Concerning the elimination of dextrose into the gastro- 
intestinal canal. 
By I. S. KLEINER. 
[From the Department of Physiology and Pharmacology of the 
Rockefeller Institute.] 
Our experiments have reference to statements in literature, 
some of which, for a better understanding of our results, may be 
here quoted very briefly. On the basis of analyses of the contents 
of the gastro-intestinal canal of seven rabbits, Fischer and Moore 
make the statement that 14 the small intestine of the rabbit contains 
no sugar, when an animal is killed shortly after having consumed 
several hundred grams of carrots and carrot tops or cabbage." J. 
B. MacCallum reported that in a few experiments with intravenous 
injection of sodium chloride which, as is well known, produces 
glycosuria he found some dextrose in the stomach and intestines 
the quantity of which was slightly increased when, previous to 
the infusion of the sodium chloride, both kidneys were ligated. 
MacCallum thought that the presence of glucose in the intestines 
under these circumstances is due to the hyperglycemia and looked 
upon it as a sort of "intestinal diabetes"; he believed further that 
in the absence of the kidneys the intestines assume a supplement- 
ary excretory function. Fischer, on the other hand, draws the 
conclusions from some experiments that hyperglycemia alone 
does not lead to a secretion of glucose into the intestines. This 
occurs only, he maintains, when the infusion of sodium chloride 
is administered to hyperglycemic animals as was the case in Mac- 
Callum's experiments on account of the use of morphine. 
In our experiments the rabbits had been fed for some time on 
hay and cabbage. The dextrose determinations were made by 
Pavy's method and controlled in some instances by Allihn deter- 
minations. Various series of experiments were carried out. 
Only the average figures of each series will be given here. In 
one series of six normal animals the contents of the stomach 
and intestines were analyzed some hours after they were fed. 
The small intestines as well as the stomach contained in 
each case small amounts of reducing substance. The averages 
