7 6 
Scientific Proceedings (42). 
In the other six cases the same arrangement of the new formed 
connective tissue in narrow radial bands which start deep in the 
pyramids was noticeable although no evidence of a septic infection 
could be discovered. The interstitial lesions were accompanied 
by marked epithelial lesions in two cases only, producing to a 
certain extent the picture of a chronic parenchymatous nephritis, 
although the lesions were never very extensive. Lesions of the 
blood-vessels or primary lesions of the glomeruli were not found in 
any case. The lesions described by the writer in his paper on 
experimental chronic nephritis 1 in rabbits 52 and 48 are probably 
spontaneous ones. Only six normal livers were encountered; the 
rest showed various stages of coccidial infection with more or less 
cirrhosis and sometimes cirrhotic processes in cases in which 
coccidia could not be demonstrated. We are very strongly of the 
opinion that our findings throw very serious doubt on the numer- 
ous reports of the experimental production of cirrhosis in the liver 
of rabbits as this animal would seem to be entirely unsuitable for 
such experiments. No gross lesions of the heart or of the aorta 
were discovered in any of the animals. 
Of the one hundred guinea pigs the large majority had been 
injected with sediment from urine or other material suspected of 
containing tubercle bacilli ; a few only actually developed tubercu- 
losis. There were several especially selected old animals. Sixty- 
three of the one hundred had absolutely normal kidneys, two 
showed slight parenchymatous lesions and in thirty-five there 
were scattered small areas of cellular infiltration in the cortex 
which were sometimes rather numerous, at other times they were 
found with difficulty only on careful examination of several sec- 
tions. They consist largely of lymphocytic cells and few larger 
cells with vesicular nuclei. They do not seem to have much 
tendency to develop into fibrous tissue although occasionally 
such a change was observed but always to a limited degree only. 
A reason for the existence of these foci could not be discovered. 
The lesions described in the writer's article on "Experimental 
Chronic Nephritis" 2 in guinea pigs as representing the early 
stages of renal lesions in chronic lead poisoning are probably of 
1 Journal of Medical Research, 1908, XVIIL, 497. 
2 Journal American Medical Association, 1907, XLVIIL, 483. 
