Action of Dog's Pancreas and Pancreatic Juice. 93 
dimension of the organ measured as before. It was found that 
the prostate increased the length 25 mm., and the width of the 
bulb 25 mm. The orchitic extracts gave an increase in length of 
15 mm., and an increase in width of bulb of 23 mm. The ovarian 
extract gave an increase in length of 21 and an increase in width of 
bulb of 23 mm. The parathyroid extract gave an increase in- 
length of 15 and an increase in width of bulb of 15 mm. The 
thymus extract gave an increase in length of 15 mm. and an in 
crease in width of bulb of 12 mm. Pituitary extract as a whole, 
gave an increase in length of 11 mm. and an increase in width of 
bulb of 6 mm. Infundibulin gave an increase in length of 5 mm. 
and an increase in width of bulb of 6 mm. Pineal gland gave no 
increase in length but increase in width of bulb of 7 mm. The 
corpus luteum increased the length 15 mm. and the width of the 
bulb 28 mm. 
56 (581) 
The depressor action of dog's pancreas and pancreatic juice. 
By A. B. EISENBREY and R. M, PEARCE. 
[From the Laboratory of Research Medicine, University of 
Pennsylvania.] 
The marked lowering of blood pressure produced by the pan- 
creatic juice of the dog when injected into the circulation of the 
dog, suggested that the sudden onset of prostration and collapse, 
symptoms indicative of vasomotor insufficiency seen clinically 
in acute pancreatic disease, might be due to the direct peritoneal 
absorption of the pancreatic juice set free in the destruction of 
the gland. 
We have accordingly collected the pancreatic juice from anes- 
thetized dogs by placing a canula in the duct, and the secretion 
so obtained was diluted with equal volumes of 0.85 per cent, salt 
solution and injected into the femoral or external jugular veins 
of the same or other dogs. Varying with the anesthetic used and 
directly with the blood pressure level at the time of injection, we 
have obtained falls of from 20 to 60 mm. Hg by injecting the equiv- 
alent of 1 c.c. of pancreatic juice. The action does not appear 
to depend on any primary cardiac effect. The fall is prompt and 
recovery to the original level occurs within 2 minutes. Pan- 
