ii6 
Scientific Proceedings (43). 
cell transported into a certain organ will form there a visible 
metastasis. All suspicious nodules found anywhere and all 
lungs appearing abnormal on gross inspection were examined 
microscopically with negative results. The same negative re- 
sults were obtained in six rats, where the injection was made into 
the carotid artery, and the animals survived. This method is 
very difficult of execution and the animals usually die a few minutes 
after the injection from respiratory paralysis, while the heart con- 
tinues its action a few minutes longer. 
Carcinoma of the White Rat (Flexner-Jobling) . — This tumor is 
not as malignant as the previous one, but metastasis occurs 
frequently after a subcutaneous inoculation. The metastasis 
is usually found in the lungs, but it was also observed by Flexner 
and Jobling in the kidney, the heart and even in the lymphatic 
glands, though the authors believe that in most cases the meta- 
stases were produced through the blood current. Sixteen rats 
received an injection of an emulsion of this tumor into the jugular 
vein. In three animals metastasis was found in the lungs, no 
other organ showed any metastasis. Six rats survived an injection 
into the carotid and of these animals one showed metastasis in 
the lungs. In another rat, in which the injection was made in the 
carotid against the stream of blood, the animal was found dead 
twelve days later. At the autopsy a nodule was found on the wall 
of the left ventricle. The animal remained dead in the cage over 
night and the specimen had greatly deteriorated, still the nodule 
resembled microscopically the picture described by Flexner and 
Jobling of a metastasis found by them in the heart. 
Sarcoma of the White Mouse. — Ehrlich has shown, that when 
this tumor is inoculated subcutaneously into a rat, there forms a 
small nodule, which remains for 8-10 days, and is then absorbed. 
No metastasis formation of this mouse tumor into a rat was ever 
noted. An emulsion of this tumor was injected into the jugular 
vein of twelve rats. The rats were killed in periods of 4-8 days 
and in two of the animals metastatic nodules were found in the 
liver. Neither in the lungs nor in any other organ was there found 
any metastasis. 
The results of these experiments seem to indicate in accordance 
with the opinion of M. B. Schmidt, that cancer cells introduced 
