Effects of Adrenalin on Urine of Dogs. 131 
milk before blood samples were taken. When twins came, one 
was placed, at once, upon cow's milk for control. At the time of 
birth none of the young showed specific hemolysins in the blood 
serum. But those getting the colostrum and first milk rapidly 
acquired, and retained, the specific antibodies. The colostrum 
in those cases was very rich in haemolysins, but the antibodies 
disappeared from the milk output after a few days, in so far as 
we were able to ascertain. 
80 (605) 
The effects of intraperitoneal injections of adrenalin on the 
partition of nitrogen in the urine of dogs. 
By JACOB ROSENBLOOM and WILLIAM WEINBERGER. 
[From the Laboratory of Biological Chemistry of Columbia University, 
at the College of Physicians and Surgeons, New York.] 
Underhill and Closson have shown that the subcutaneous 
injection of adrenalin chlorid solutions into dogs is not attended 
by any significant change in the proportion of the urea, ammonia 
and creatinin nitrogen of the urine. 
In our work we used two specimens of the colorless adrenalin 
chloride, 1 :iooo, of Parke, Davis and Co. They were purchased 
in the open market. Each was tested for its pressor action at the 
conclusion of the corresponding injection experiments and was 
then found to be practically as active as ever. 
The metabolism experiments were carried out by the methods 
in use in this laboratory. 
Intraperitoneal injection of adrenalin chloride solutions was 
without effect on the proportions of nitrogen in the forms of urea, 
ammonia, creatin and creatinin, purins and allantoin. 
In one adrenalin injection period of eighteen days, a total of 
62 c.c. of a 1:10,000 adrenalin solution was given intraperitoneally 
and in another injection period of six days a total of 29 c.c. of a 
1 :iooo adrenalin chloride solution was administered. 
The following table shows the different percentages of nitrogen 
for the several experimental periods : 
