464 
THOMPSON YATES LABORATORIES REPORT 
six thousand were present in the blood per c.mm. ; next day temperature reached 
105*8°, with a drop to 102° on the following day, when no parasites were found. 
This rise and fall of temperature was again repeated with a corresponding appear- 
ance and disappearance of parasites, followed by another period in which the 
parasites gradually increased in the blood up to the time of death on November 6. 
The course of the disease presents a remarkable similarity to that recorded by 
Evans and Steel amongst the Surra cases in India and Burmah. 
The symptoms presented in the South American disease, Mai de Caderas, are 
very similar to those of Surra and Nagana ; haematuria is a very frequent accompani- 
ment and weakness and paralysis of the hind legs are the most pronounced 
features. 
With regard to Dourine, or Maladie de la Coit, the symptoms presented in this 
disease are of a much less severe character. In the horse there is rarely fever. The 
disease shows itself in the horse after coitus in ten to twenty days, and lasts four to 
ten months, with swelling of the genital organs. Other symptoms present are pro- 
gressive emaciation, oedema of the abdominal regions, swelling of the pastern, and 
weakness of the hind legs. Towards the end, eye troubles set in, paraplegia and a 
cutaneous eruption have been observed. 
The parasites are always rare in the blood, occurring for the most part in the 
sero-sanguinolent fluid of the local oedemas under the cutaneous plaques, and on the 
mucous membranes of the vagina and urethra. 
Laveran and Mesnil 1 state that Nocard has been able to kill horses by inocu- 
lating the trypanosome of Dourine in four, six, and eight weeks, and they show a 
temperature curve of Nagana and Surra. 
Chart No. 4 shows the character of the temperature and the relation of parasites 
occurring in the blood (indicated by dotted curve) in an ass inoculated with T. brucei 
by Laveran and Mesnil. 
If the above symptoms in animals are compared with those described as occurring 
in man, it will be seen that they have many points in common ; the same cachectic 
symptoms — loss of flesh, weakness, similar eye symptoms, oedema, etc., accompanied 
by an irregular relapsing fever, associated with the disappearance of the parasites after 
the pyrexial attack. Though there is as yet no experimental evidence that the symptoms 
described in this case result from the presence of the trypanosome ; yet here we have 
a case presenting peculiar clinical features which do not show much resemblance to 
any known disease, and along with them is a pathological agent, allied species of which 
cause similar symptoms in (he lower animals ; for this reason I think it is justifiable 
to consider this case as akin to Surra or Nagana occurring in man. 
1. Laveran and Mesnil, Sur le Trypanosome du Naguna ou Maladie de la Mouche Tsetse, Annates de Vlnstitut Pasteur, Jan. 25, 1902 
