34 THOMPSON YATES AND JOHNSTON LABORATORIES REPORT 
low that they seem at first sight to he oedematous. At times a slight watery dis- 
charge from the eyes may be observed. In none of the horses have we observed 
the marked oedema ot abdomen, scrotum, and legs, nor the staring of the coat which 
is described in horses suffering from Nagana. 
This last stage has lasted in one ot our horses (Case VI) for ten months, and 
during this time on only four occasions have parasites been seen in his blood. On 
each occasion their presence was accompanied by a slight rise in temperature to 103 0 F., 
or thereabouts. 
As the disease proceeds, emaciation becomes more and more marked. The 
ribs and ilia stand out prominently. The animal wears an apathetic chronically- 
tired expression which is most characteristic. No oedema is to be made out. A 
whitish discharge from the eyes, in small quantities, is often seen. Saddle galls and 
sores on the projecting hip bones are often present. No haemorrhage has been observed 
in any of the mucous membranes. No blood has been seen in the urine. 
The parasites are now often almost continuously present in the blood and may 
reach very considerable numbers. Case V, however, presents a most notable contra- 
diction to this generalization. 
The temperature fluctuates, though it is generally raised, and may go up as 
high as 105 0 F. 
Two horses have died under observation. One lingered for three days, 
scarcely able to rise from the ground, in a state of utter weakness. His breathing 
was very laboured, he sweated almostly continuously, and just before death had a 
slight convulsive seizure (Case I). 
The second animal died suddenly one day after being taken out a little distance 
to graze. In this animal a few conjunctival petechial haemorrhages were seen (Case V). 
The most notable features observed in the autopsies of these two animals were 
the yellow gelatinous oedema fluid found round the sheath, and in the first case, on 
the abdomen, and the amber-coloured fluid with flakes of yellow gelatinous lymph seen 
in the peritoneum and in the pericardial and pleural cavities. There was a general 
enlargement of all lymphatic glands. Some were soft, amber-coloured, and watery, 
others had a chocolate-coloured centre, and still others shewed marked petechial 
haemorrhages ; some were entirely haemorrhagic. Spleen was not enlarged. Lungs 
were congested. Liver shewed fatty change. In one case the heart shewed marked 
fatty degeneration (thrush heart). To the naked eye there was no change in the 
bone marrow. 
Only in the very last stages of the disease does any marked alteration in the 
blood seem to take place, then both red cells and haemoglobin are diminished. 
Duration of Disease. — How long the disease lasts we cannot at all say. We 
have now (November, 1903) under observation, a horse (Case VI) which we bought 
in November, 1902, in good condition (first stage). We believe that it contracted 
the disease at least a month before. 
