A NEW PARASITE OF MAN 
8 1 
to 3*5 m in diameter. The cell wall is stained red, and the colour fades inwards, 
leaving a clear area round the macronucleus. The twin nuclei have exactly the same 
appearance and relative position as in the embedded forms. They lie usually at the 
ends of the minor diameter of the elliptic cell, and the macronucleus often bulges 
beyond it. I can find no definite examples in my preparations of division of either 
nucleus ; nor any suggestion of coupling of the bodies. 
The free forms are much more numerous than the embedded forms. In the post- 
mortem specimen, there are about thirty in a field ; in the others they are less numerous, 
but larger, and possess a more definite cell wall. Of the many thousands of the free 
forms contained in the specimens made intra vitam, I can find only two or three lying 
apparently in the red cells (which are well preserved in these preparations). Two of 
these are given in the drawings (Figs. 31, 32) ; but I think such instances should be 
explained by accidental superposition, and are too rare to warrant the theory that the 
bodies are generally intracorpuscular. They appear to me to lie tree in the serum. 
It should be noted that in the two intra vitam specimens, especially in one 
of them, the nuclei ot many of the leucocytes exhibit curious massive nodular deeply- 
staining granules, arranged principally round the periphery of the nucleus. I am not 
familiar with such granules ; but cannot definitely connect them with Leishman's 
bodies. 
There appears to me to be nothing to suggest that the parasites are degenerate 
trypanosomes. I have not found a single trypanosme, nor even the flagellum of one, 
in any of the preparations. Other reasons have been given in my previous paper' 4 ' ; 
though Leishman still contests the point. In my humble opinion, more is to be said 
for Laveran's view — that they belong to the Piroplasma group ; but I do not find, 
as he does, that they are ever piriform, or intracorpuscular, or that they show signs of 
bipartition. 
So far as I can judge from the three preparations, the individual Leishman 
bodies appear to me to be spores given off from the protoplasmic matrices ; which, 
in their turn, would seem to be relics (e.g., portions of the bioplasm) ot the parent 
organism, of which the entire forms have not been seen. The evidently immature 
condition of the bodies within the matrices is further suggestive of this view. 
Laveran has named the organism Piroplasma donovani. But if my view 
proves to be right — if they belong to a new genus of Sporozoa — I would suggest the 
name Leisbmania for that genus. The full name would then be Leishmania donovani, 
Laveran. 
Leishman and Donovan have already connected the parasites with the 
chronic fever, anaemia, and enlargement ot the spleen which constitute a pathological 
condition enormously prevalent in India. From Donovan's charts, I recognize the 
clinical picture at once, and agree with Leishman that it is very similar to that of 
Ka/a-azar. Ot course many such cases may be merely chronic malaria ; but in 
