19 
early or late fatty or parenchymatous change. The distortion was due to the 
presence of accumulations of large lymphocytes of various size and shape. 
They seemed to begin in the interstitial tissue and rapidly invade the paren- 
chyma. They were quite compact and well preserved, in three cases only a 
central softening being present. The connective tissue was not increased, the 
blood vessels were not affected, and only once were the bile ducts the seat of 
an acute inflammation. A few crystalline eosinophiles, polynuclears and 
round cells were encountered in these cellular masses. The capsule was 
frequently edematous and occasionally infiltrated with large lymph cells. 
The heart was only affected once, showing cloudy swelling of the musculature. 
The pericardium was once the seat of gelatinous pericarditis, but often a great 
number of lymphocytes were found scattered irregularly beneath the mem- 
brane. 
The Spleen. This organ was enlarged two to three times, smooth, firm, with 
the capsule spanned over it and the pulp springing out on section. It was 
usually purplish in color with indefinite gray mottlings distributed irregularly 
through it. The follicular identity was absent and the organ made up of a 
more or less equal admixture of small and large lymphatic cells, hyperplastic 
endothelium with a few eosinophiles. The endothelium was not confined to 
the centre of the follicles and the lining of the sinuses, but was diffusely dis- 
tributed. The connective tissue was not increased, but the capsule was 
edematous and contained numerous large lymphocytes. Phagocytosis and 
pigmentation were not excessive. None of the large lymphatic cells were 
found phagocyting. The kidney shows little or no change macroscopically, 
but histologically a cloudy swelling was usually present. Accumulations of 
large lymphatics were twice found in the medullse. The adrenals were usually 
rich in cells, but no accumulations were found. 
The ntestines were always swollen out with a yellow or yellowish gray 
granular material. This consisted chiefly of cellular debris, since little food 
was present. The coats of the gut were thickened, apparently edematous to 
the naked eye, and always congested. On two occasions definite small hem- 
orrhages were found. The duodenal loop was most often affected. There 
was present, under the microscope, an enteritis varying from simple catarrhal 
to hemorrhagic. The sub-mucosa was the seat of large lymphocytic accumula- 
tions in eight of eleven cases, very extensive in a few instances. Follicular 
masses were not prominent, indeed small round cells were rather rare. No 
degeneration of these masses had occurred. 
The serous membranes, notably the peritoneum in the space behind the 
proventricle, spleen and stomach, in front of the kidney, and above the coil of 
the intestine, were the seat of a sub-fibrinous inflammation three times, and 
histologically these membranes were almost always the seat of more or less 
lymphatic invasion. 
The bone marrow was hyperemic to the naked eye. Microscopically the 
predominating cells were the large lymphocytes and the neutrophilic myelo- 
cytes. No accumulations of the former were encountered. The general 
structure of the marrow was very little disturbed. The blood was aleukemic. 
A few myelocytes were present. The morphology of the blood elements 
seemed normal. These observations were made on four birds. 
Bacteriology. Cultural tests were not made on five birds because of the 
length of time elapsing between death and autopsy. In two more no growths 
were obtained, in another a Str. brevis was isolated. In the other three, an 
organism indistinguishable from the Bacterium sanguinarium was isolated. 
