23 
from both sides. There was no disturbance of the rectal 
or bladder functions, although at the autopsy the bladder 
was full. 
Death occurred on December 2d. 
At the autopsy the brain and spinal cord, with the other 
organs, were examined. The dura was adherent to the left 
side of the brain, in the prefrontal region, in the upper third, 
and when the brain was removed it was observed that an 
area of softening lay beneath this point. A small caseous 
mass was also observed at the base of the right lung, and 
beneath the diaphragm on the right side was a large abscess, 
partly involving the liver. The tubercle bacillus was found 
in the pus removed from the area of softening beneath the 
left cortex. 
A study of the brain revealed the presence of three foci 
of softening. The largest one was situated in the left hemi- 
sphere in the prefrontal region, and extended from just 
beneath the cortex in the upper third of the region, down- 
ward almost to the base of the brain. This area was cylin- 
drical in shape, and measured 2^ centimeters in its greatest 
diameter. The area of softening consisted of caseated 
material and pus, in which the tubercle bacillus w^as found 
present. 
A second area of softening was found on the right side 
of the brain, much smaller in extent and measuring about 
centimeters in diameter. There was no pus present in 
this area, but it consisted of a circumscribed mass of caseous 
material. The apex of this area of softening was just be- 
neath the cortex in the prefrontal region on the right side, 
and in the removal of the brain the cortex was torn just 
above this area of caseation. This point was i a centimeter 
in front of the central fissure, and about 1 centimeter below 
the superior surface of the brain. 
A third area of softening was observed posteriorly, in the 
white substance, in the parie to-occipital region, and measured 
about six millimeters in diameter. 
A study of the sections of the brain shows beautifully the 
extent of the destruction of the brain tissue. The optic 
thalamus and the lenticular nucleus, and the posterior limb 
