30 
neoplastic effect of the worms is very striking and calls to 
mind the observations of Fibiger. This pathologist 
found an adeno-carcinoma in the stomach of rats due to a 
nematode transmitted by the cockroach. His observa- 
tions and work seem acceptable and are unique. Tumor 
of the pituituary. The position of the pituituary is 
occupied by a wide flat mass 40 x 50 mm. of a red gray 
color and firm uniform consistency. 
Anemias. 
During the year four cases of what was probably 
primary anemia occurred, three in monkeys and one in a 
bassaris. In all cases careful search was made for para- 
sitic infestation without such a discovery, and, in three 
cases, two monkeys and the bassaris, the investigations 
included a thorough hunt for a focal infection. 
Animals do not frequently come to autopsy with a 
picture similar to that of pernicious anemia of the human 
being, so that when one meets the complete picture, as 
shown by the Japanese Macaque No. 16, the impression 
is distinct. The case in which this occurred is given in 
detail. The other cases are merely listed. 
Note. — No. 4046 Japanese Macaque No. 16. Drooping since Augu.st 24th, 1916. 
Died September 12th, 1916. Aplastic anemia, chronic hypertrophic gastritis, atrophy 
of heart muscle with regeneration, hemosiderin pigmentation of liver, perilobular fibrosis 
of liver, slight cloudy swelling of liver, chronic diffuse nephritis (subcapsular type), con- 
gestion of spleen, filjrillar fibrosis of spleen, hemosiderin pigmentation of spleen, local 
amyloid infiltration of spleen, calcareous infiltration in medulla of adrenal. Coat is only 
fair, body emaciated, muscles pale and fat scanty. Respiratory tract normal throughout 
save for slight emphysema. Epicardium thickened and slightly diffusely congested. 
Heart muscle pale, soft and flaccid. Liver slightly decreased in size, smooth surface, 
sharp edges, hard, rusty brown color, with a glistening smooth and moist section surface. 
Gall bladder is distended with fluid green bile and the duct is patulous. Spleen is of 
normal size, firm, smooth capsule, showing dark reddish brown section surface with dis- 
tinctly visible trabeculse. Kidneys are decreased in size, of hard consistency, pinkish 
gray color, capsule smooth and strips easily leaving a smooth surface. There is poor 
demarkation between cortex and medulla. Adrenal has thick orange yellow cortex and 
solid small brown medulla. Stomach is distended with gas and a small quantity of yel- 
lowish brown mucus, mucosa everywhere normal. Postmortem blood examined and 
stained by Romanowsky but the red cells are disintegrated so examination is unsatis- 
factory. 
Histological Notes. — Heart shows normal epicardium quite free of fat. Myocar- 
dium is peculiar in that the fibers immediately under epicardium show marked broadening 
in a very narrow rather sharply indicated zone where nuclei are extremely large although 
not specially chromatic; transverse markings here easily although faintly recognized; 
the fibers have very indefinite borders, their longitudinal fibrillae being ranged in form 
of a course reticulum; this comes about from frequent and extensive lateral anastomoses 
with fellow fibers giving appearance of a syncitium. In deeper parts fibers are of more 
common size but nviclei are still large and fibers, now cut in transverse section, do not 
appear to anastomose so freely. There appears to be a slight excess of fibrous tissue in 
