32 
thyroid retained the foetal type and was approximately 
correct in size. In 1915, a year after the birth of these 
two, she gave birth to seven pups, two of which died 
almost immediately and were not posted. The other five 
died in from two to seven months and were all cretins or 
cretinoid. These beasts all show imperfect development 
of the skeleton and retention of a large amount of carti- 
laginous structure. Two of them had hemorrhagic 
pachymeningitis, one being the external form. The 
pituitary body was not anatomically altered. The father 
of these litters died on the 11th of May, 1915, of acute 
fermentative gastritis, with dilatation. He showed foetal 
adenoma of the thyroid. The pituitary was lost, but it 
was not grossly altered. He was a well developed speci- 
men and showed no evidences of goitre or myxcedema. 
On March 31st, 1916, seven pups were born. One was 
killed because it was a cretin; a second was killed because 
it was a runt and could not move around, a disability 
found to be due to fracture of both femora. Five remain 
alive, three of which are runts ; the other two are normally 
formed, fair specimens, except for weakness of the hind 
legs. The runts show some enlargement of the neck; 
the larger ones do not. The mother was recently ex- 
amined and showed no thyroid enlargement. The father 
is a splendid specimen of the gray timber wolf without 
any thyroid enlargement. Beginning late in June, these 
runts were fed with chopped horse thyroid. One markedly 
improved, another slightly, a third not at all; this one 
may have been too weak to get his portion of food. The 
noteworthy points in the history are : First, the throwing 
of two litters of preponderantly cretin pups by a perfectly 
healthy mother and good specimen, following the first 
litter of pups, which were apparently normal; secondly, 
the presence of goitre in one father and its absence in the 
father of the last litter. This carries out previous observa- 
tions that cretinism may be carried by the mother; 
thirdly, while there is an imperfect development of the 
skeleton, it is in most cases an orderly development as 
far as it goes and is architecturally correct, the outlines 
