32 * NAT. ORDER. CINCHONACE/E. 
duce into notice in this place only the medical properties and for- 
mularies for the exhibition of the cinchonine and quinine. M. Ma- 
gendie says — ■" a sufficient number of cases induce me to believe 
that these two alkalies (cinchonine and quinine) possess the medical 
properties of the cinchonas, and may be substituted for them on all 
occasions. In the twelfth volume of the Medico-Chiurgical Trans- 
actions, Dr. Elliotson of London has sufficiently established the feb- 
rifuge efficacy of both simple quinine, and of the sulphate, which is 
further confirmed by Dr. Dickson of Clifton, in the Edinburgh Med- 
ical and Surffical Journal." For us to insist on the value of these 
O 
preparations is needless; since their introduction into some of the 
ague districts of our Western States, their use has become general, 
and seldom fails to effect a cure. As a general tonic, both the cin- 
chonine and quinine may be successfully exhibited, in all cases where- 
in the cinchona would be indicated. The sulphates are the prepa- 
rations most generally employed, and are recommended from one 
to eight grains to be given in twenty-four hours. Some physicians 
have thought it necessary to carry the dose much higher, but in 
general the result has not answered their expectation, and some pa- 
tients have experienced severe symptoms, such as great agitation, 
with strong cerebral excitement. 
" The United States Dispensatory recommends the introduction 
of this bark, occasionally, into the system by other sources than 
that of the stomach, where it has been found to exercise its pecu- 
liar influence whenever applied. Injected into the rectum, with 
opium to prevent purging; also in intermittants. Bark jackets, and 
baths, have been found servicable. But the best preparation of 
bark for external application is decidedly sulphate of quinia, which, 
sprinkled upon a blistered surface, denuded of the cuticle, is speed- 
ily absorbed, and produces on the system effects not less decided 
than those which result from its internal administration " 
