I 
NAT. ORDER. CINCHONACEiE. 33 
Dr. James Osgood, of Boston, Mass., informed me that while he 
was engaged in the practice of medicine in some of our Western 
States, in the years ,1846 and 1847, he made extensive use of the 
Cinchona, in the treatment of fevers so prevalent in that portion of 
the country; and in all cases where the directions had been faith- 
fully attended to, the chills and fever were invariably broken up, 
either on the second or third day. He advises its use in connection 
with other articles, and compounded after the following manner, 
viz. : Take equal parts of cinchona ruba peruvian bark, diospyros 
virginiana persimmon bark, (of the root,) and corallorhiza oclontor- 
hiza crawley root. Let them all be finely pulverised and well mix- 
ed together, and exhibit half an even tea-spoon full in a gill of cold 
water, once an hour, for six hours. This treatment," says Dr. Os- 
good,. "I have usually preceded with an emetic, and have invaria- 
bly found it efficacious in removing the febrile symptoms within the 
time above specified. In very severe cases I have added to each 
dose one or two grains of Quinine. This mode of treatment is ap- 
plicable to all the fevers of the Western country, and is decidedly 
the best that I have ever pursued. It produces speedy and profuse 
perspiration, to which the fever shortly yields. 
How far the same treatment would be applicable to the fevers 
of this region, I am unable .to determine, having had but a single 
opportunity to test it. That was a case of Pleurities, pleuricy, in 
which it equalled my most sanguine expectations. It may be well 
to remark that it would be injudicious to continue the use of the 
medicine longer than about six hours, as the perspiration would 
cause too much debility. In connection with the treatment it is my 
uniform practice to keep the bowels open." 
TINCTURE OF QUININE. 
Take of sulphate of Quinine - - G grs. (gr. 4. 92 troy.) 
Alcohol of 34° (847) - - 1 oz. (7 dr. 52. 5 gr. troy.) 
We are told that the sulphate is to be preferred to the pure 
quinine, in this case ; because when the tincture is made by using 
