532 Proceedings of the Royal Society 
ilone the epithelial cells lose their granular appearance, and their 
outlines can be more readily traced. In a favourable specimen you 
may then see clearly the slight spaces between each cell converg- 
ing towards the centre of the tubule, the interstices taking some- 
what the appearance of a leech bite. 
In other tubules the same appearance may be seen in a more 
modified degree — the cells swollen, but not to such an extent as 
entirely to block up the tubule. In other parts of the section 
tubules may be seen entirely denuded of their epithelium. In 
longitudinal sections these appearances cannot be so well seen. 
A consideration of these facts leads to the following conclu- 
sions : — 
I. That a mixture of glycocholate and taurocholate of soda 
when injected hypodermically, in rabbits, in doses of 40 grains 
and under, does not cause any immediate disturbance, but is almost 
always fatal (unless the dose be small) in a period varying from 
30 hours to 3 or 4 days. 
II. That such injections often cause an increased nitrogenous 
excretion by the urine. 
III. That such injections frequently cause diarrhoea. 
IV. That such injections are followed by an excretion of a small 
amount of bile acid by the urine invariably, and in some cases that 
bile figment is also so excreted. 
V. That such injections are followed by a fatty degeneration of 
the hepatic secreting cells, and of the renal epithelium. 
VI. That such injections cause a destruction of red blood 
corpuscles, and consequently an apparent increase of the white. 
VII. That such injections are frequently followed by drowsiness 
and somnolence. 
It would be out of place to attempt to give here a detailed account 
of the bearing which those results may have on liver disease. It 
may, however, be right to indicate in a brief way a few of those 
points which seem to be of special clinical interest. 
And, first, in regard to phosphorus poisoning , where the liver, 
kidneys, and muscular fibre become fatty. No true analogy can be 
traced between the results of these experiments and this disease, 
