On a Crystalline Globulin occurring in Human Urine. 
By D. Noel Paton. 
(From the Laboratory of the Royal College of Physicians of Edinburgh.) 
(Read March 7, 1892.) 
In October 1890, Dr Bramwell sent to the Laboratory a small 
quantity of urine, with a request that I should give him a report 
upon it. To him I am indebted for the opportunity of making the 
series of observations here recorded. 
On examination, I found that the amount of proteid was enormous, 
and that it was made up almost entirely of a globulin : — 
Total proteids, . . . . . .2*00 
Albumin, . . . . . . . 0’08 
Globulin, , . . . . . . 1’92 
This condition of the urine persisted, with only slight changes, 
until the death of the patient. 
The results of the analyses made at different dates are given 
below. 
November 24, 25, and 26, 1890. 
24.11 
11 P.M. 
25.11 
12 NOON. 
25.11 
6 P M. 
25.11 
11.30 P.M. 
26.11 
7 A.M. 
Total proteids. 
4-80 
2-000 
1-500 
2-500 
3-250 
Albumin, . 
0-087 
0-087 
0-160 
0-130 
Globulin, . 
1-913 
1-413 
2-340 
3-120 
Albumin, . 
0-045 
0-061 
0-068 
0 044 
Globulin, . 
The slight rise in the quotient towards the end of the day corre- 
sponds to what has been found in regard to the influence of food 
on the proteids in ordinary Bright’s disease (Lecorche and Telamon 
and Noel Paton, Brit. Med. Jour.^ vol. ii. 1890). 
