109 
1891 - 92 .] D. Noel Paton on Crystalline Glohulin. 
They appear to contain more carbon and nitrogen than this 
globulin from the urine. 
It is unnecessary here to enter upon a discussion on tlie recent 
literature on the crystallisation of various proteids. An admirable 
resume will be found in Bunges’ Physiological Chemistry (translated 
by Wooldridge, p. 54). 
Relationship to known Globulins of Animal Body. — It is difficult 
to identify this proteid with any of those known to occur in the 
animal body. 
It undoubtedly belongs to the group of globulins of which 
Myosinogen, Fibrinogen, and Halliburton’s Hepato-globulin are 
members, agreeing with them in its temperature of coagulation. It 
differs from Myosinogen in its solubility in more concentrated solu- 
tions of sulphate of magnesia and chloride of sodium, and in its 
not precipitating on the addition of acetic acid, and in the absence 
of any tendency to form Myosin. 
From Fibrinogen it differs also in its greater solubility in neutral 
salts, and from 1;he absence of any tendency to coagulate as fibrin. 
Its distinction from the less known Hepato-globulin is less clearly 
defined, and at present I am engaged upon an investigation on this 
substance. The intense fatty degeneration of the liver, observed 
post-mortem, may point to some connection between the urinary 
globulin and that organ. 
None of these proteids have been described as occurring in a 
crystalline condition. 
That it is not connected with the Globin of the red-blood 
corpuscles seems to be indicated by its coagulation temperature. 
Haemoglobin coagulates at 73° C. 
That it is not Myoglobulin is shown by its lower coagulation 
point, and by the fact that it does not require saturation with 
sulphate of magnesium to precipitate it from its solutions. 
Circumstances determining Crystallisation. — The precipitation of 
the crystals of globulin was usually delayed till some days after that 
on which the urine was passed — on many occasions it did not appear 
for several weeks. 
Whether this deposition corresponds to a loss of acidity has not 
been definitely investigated ; but certainly the urine was markedly 
acid, even after the deposition of the crystals had occurred, as is 
