491 
1907-8.] On the Effects on Metabolism of Chloroform. 
1. Total Nitrogen. — These two experiments show no definite change in 
the total nitrogen excreted, although in the second experiment a possible 
rise is masked by the fact that the dog did not take all its food. 
2. Urea Nitrogen. — In Experiment IX. there is a distinct fall in the 
proportion of urea nitrogen during three days after the administration of 
chloroform, reaching its maximum, 18 per cent., on the third day. In 
Experiment X. the fall is slight, less than 5 per cent., and is delayed 
till the fifth day. 
3. Ammonia Nitrogen. — In Experiment IX., on the third day, the day 
of the most marked fall in urea nitrogen, there is a rise in the proportion 
of ammonia nitrogen, and the same thing occurs in Experiment X. on the 
fifth day. 
4. Creatinin Nitrogen. — In neither experiment is there any marked 
change in the proportion of creatinin nitrogen. The total amount excreted 
varies fairly directly with the excretion of total nitrogen. 
5. Uric Acid Nitrogen. — In Experiment IX. the proportion of uric acid 
nitrogen is markedly raised, especially on the day of the lowest excretion 
of urea nitrogen. In Experiment X. the change is not evident. In both 
experiments there is a distinct increase in the total excretion of uric acid 
nitrogen ; in the first, upon the third day after the administration of chloro- 
form, and in the second, upon the first and second days after. 
6. Nitrogen not in these Combinations. — In the first experiment there 
is a distinct rise upon the second and third day after the chloroform. In 
the second experiment a very doubtful rise occurs upon the sixth day. 
7. Sulphur. — The sulphur was estimated in the first experiment only. 
The proportion of oxidised sulphur shows a marked decrease, beginning on 
the day after the chloroform, and reaching its maximum on the third day 
after — the day of the greatest fall in urea nitrogen. 
In both these experiments proteins were present in the urine, and in the 
first fatty cells resembling renal epithelium were seen. They were unfortun- 
ately not examined for in the second experiment. In neither experiment 
was there any marked reduction of Fehling’s solution. 
