500 Proceedings of the Royal Society of Edinburgh. [Sess. 
same operator and to the same extent for ten minutes. One was then put 
in the small cage, and the other in a large stall where it moved about 
freely. Both were killed at the end of two hours. In the first, 19’4 mg. 
of chloroform per 100 c.cm. of blood were found ; in the second, only 4‘5 
mg. (LXVII. and LX.). This observation suggests the importance of 
adequate respiration in the post-anaesthetic condition. 
Chloroform by the Stomach. 
The rabbits were anaesthetised with ether, and a catheter was passed 
down the oesophagus and a measured quantity (10 c.c. = 1 c.c. chloroform), 
of a 1 in 10 mixture of chloroform in olive oil was run into the stomach. 
The animals were killed at varying periods after the administration of the 
drug. 
No. 
Weight. 
Time after 
Administration. 
Amount of CHC1 3 
in Blood. 
Remarks. 
IV. 
2100 grms. 
35 minutes. 
11*3 and 11*8 
XL. 
1300 „ 
3 hours. 
32-5 
Very staggery. 
XXXVII. 
1100 „ 
4| „ 
16* 
Recovered immediately. 
XXX. 
1620 „ 
» 
25- 
( 
2J hours after, staggery. 
XLL 
950 „ 
55 
19*3 1 
5^ hours after, recovered 
completely. 
XLVI. 
1900 „ 
55 
14-9 
LIII. 
1550 „ 
6|- 55 
4- 
It appeared to us that very possibly with the mode of administration 
an accumulation of chloroform might take place in the liver. Two or three 
observations were made upon the amount of chloroform in that organ : — 
No. Time. Liver. Blood. 
XL. 3 hours 36'2 32 ‘5 
XXX. 4J „ 21-3 25 
Tissot (0. R. Soc. biol ., 1906, p. 205) and Nicloux (C. R. Soc. biol., 1906, 
p. 208) have found that when chloroform is administered by the respiratory 
passages the percentage in the liver is far below that in the blood, and 
this conclusion we can confirm from our own observations. In one rabbit, 
chloroformed for ten minutes and killed a few minutes later, when just 
recovering from the anaesthetic, the blood contained 31 ’4 mg. per cent, and 
the liver only 15*2 mg. per 100 cm. Hence our results help to explain the 
more marked action of chloroform on the liver when administered by the 
mouth. 
