1910-11.] Bone Growth in absence of Functioning Testicles. 101 
Although the work here reported was primarily undertaken in connec- 
tion with a general study of giantism, the scope of the present communica- 
tion is limited to a consideration of those cases of abnormal bone growth 
which are associated directly with the removal by operation or disease, or 
with the developmental failure, of functioning testicles. Giantism as a 
whole is not discussed, neither is physiological giantism, nor any of the 
numerous class of cases of giantism associated with other disturbances of 
the metabolism of the body. 
The problems which it has been attempted to solve are — 
1. What disturbances occur in the orderly development of the skeleton 
in men and animals who have been deprived of functioning sexual glands 
by developmental error, operation, or disease ? 
2. What is the cytological process by which these alterations are 
brought about ? 
3. What is the explanation of their varying manifestations ? 
The record of the search for definite answers to these questions has 
divided itself naturally into three parts : — 
1. Anatomical and Anthropological. 
2. Histological and Physiological. 
3. Anatomical and Anthropological ( continued ). 
These are the titles of the three principal parts of this communication. 
SECTION I.— ANATOMICAL AND ANTHROPOLOGICAL. 
Observation 1. 
Description of the Body of an Anorchid dissected at the 
Royal College of Surgeons in Ireland. 
Subject No. A 9. — Age 28. Male (?). Cause of death — Pulmonary 
tuberculosis. Stature (measured on autopsy table) — 1732 mm. 
General Description. — The subject was thin and ill-proportioned. 
His limbs were long, his trunk short. Within the trunk the thoracic 
segment was disproportionately long. The cheeks were extremely 
hollow. The skin was freckled and glabrous. The penis and testicles 
were small. 
Examination of the Body. — The first step in the dissection of the body 
was to remove the testicles and to have them prepared for microscopic 
examination. 
Thereafter the body was preserved by the in tra- vascular injection of 
formalin 15 per cent, solution. 
